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Table 1 Baseline characteristics of patients with Type 2 diabetes and prediabetes

From: Leptin mediate central obesity on the severity of cardiovascular autonomic neuropathy in well-controlled type 2 diabetes and prediabetes

 

Prediabetes (n = 17)

Diabetes (n = 90)

P-value

Characteristics

Age (year)

63.3 ± 12.8

67.3 ± 8.1

0.21

Sex (male/female)

11/6

50/40

0.49

Diabetes duration (year)

–

11.5 ± 8.6

 

Body mass index

24.3 ± 2.5

27.1 ± 4.6

0.001*

Waist circumference (cm)

85.3 ± 7.5

94.6 ± 11.7

0.001*

SBP (mmHg)

131.6 ± 14.8

137.8 ± 17.9

0.07

DBP (mmHg)

76.9 ± 8.2

76.5 ± 12.5

0.90

Baseline underlying disease

Hypertension (%)

11 (64.7%)

68 (75.6%)

0.38

Coronary heart disease (%)

2 (11.8%)

11 (12.2%)

1.0

Cerebrovascular events (%)

4 (23.5%)

33 (36.7%)

0.30

Hyperlipidemia (%)

14 (82.4%)

71 (78.8%)

1.0

Chronic kidney diseases (%)

2 (11.8%)

47 (52.2%)

0.002*

Retinopathy, n (%)

5 (29.4%)

71 (78.9%)

0.24

Proteinuria, n (%)

0

37 (41.1%)

0.001*

Laboratory test findings

Total cholesterol(mmol/L)

169.6 ± 27.5

156.4 ± 34.2

0.135

Triglyceride(mmol/L)

119.4 ± 70.7

140.7 ± 75.6

0.286

HDL-C (mmol/L)

53.2 ± 11.2

45.6 ± 11.2

0.017*

LDL-C (mmol L)

91.8 ± 21.1

85.3 ± 26.7

0.348

HbA1c (%)

6.0 ± 0.3

7.1 ± 0.8

 < 0.0001**

eGFR

78.1 ± 25.8

57.3 ± 25.3

0.002*

UACR

5.8 (3.6, 7.2)

17.3 (8.5, 85.3)

 < 0.0001**

TG/HDL ratio

2.5 ± 1.8

3.4 ± 2.1

0.11

HOMA-IR

2.4 ± 2.3

3.5 ± 2.7

0.135

hs-CRP

0.6 (0.3, 2.7)

0.9 (0.6, 2.0)

0.336

Type of diabetes treatment

OHA only (%)

0

74 (82.2%)

 

Insulin only (%)

0

4 (4.4%)

 

Insulin + OHA (%)

0

7 (7.8%)

 

Diet control without medication (%)

17 (100%)

5 (5.6%)

 

Other concomitant medications

ACE inhibitor or ARB (%)

11 (64.7%)

65(72.2%)

 

Beta-blocker (%)

3(17.6%)

28 (31.1%)

 

Calcium channel blocker (%)

4 (23.5%)

45 (50%)

 

Diuretics (%)

3 (17.6%)

18 (20%)

 

Antiplatelet medications (%)

4 (23.5%)

26 (28.9%)

 

Statins (%)

13 (76.4%)

70 (77.8%)

 
  1. Data are presented as means ± standard deviations or median (IQR)
  2. n number of cases, IQR interquartile range, SBP systolic blood pressure, DBP diastolic blood pressure, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, HbA1c glycohemoglobin, eGFR estimated glomerular filtration rate, hs-CRP high-sensitive C-reactive protein, UACR urine albumin-creatine ratio, HOMA-IR homeostasis model assessment of insulin resistance, TG/HDL Triglyceride/LDL-C, OHA oral hypoglycemic agent, ACE angiotensin-converting enzyme, ARB angiotensin II receptor blocker
  3. * indicates that p value < 0.05.
  4. ** indicates that p value < 0.0001
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Journal of Translational Medicine

ISSN: 1479-5876

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