Fig. 6

CAD associated microbiota evoke Th17 response and impaired gut permeability in the small intestine. a Proportions of RORγt⁺ T cells within the CD4⁺ T cells compartment in the spleen. n = 11 per group. b Plots of Tregs gated on CD4⁺CD8a⁻CD25⁺Foxp3⁺ (left); the percentages of Tregs in spleen (right). n = 8 per group. c Proportions of Th17 cells (CD4⁺CD8a⁻IL17a⁺) within the CD4⁺ T cells compartment in the siLPL. n = 11 or 12 per group. d Plots and percentages of Tregs in the siLPL. n = 11 or 12 per group. e Plots and percentages of DCs (CD11c⁺CD103⁺) in the siLPL. n = 4 or 5 per group. f Th17/Treg cell count ratio of siLPLs. n = 10 or 11 per group. g Claudin-1 and ZO-1 expressions in the ileum. n = 11 or 12 per group. Mann–Whitney t-test was used to compare groups, and error bars represent Means ± SEMs. *P < 0.05, **P < 0.01. siLPL, small intestinal lamina propria lymphocytes; DC, dendritic cells; Tregs, regulatory T cells