Fig. 7
Effect of GSZD on histologic lesions of AIA rats. a Inflammatory changes observed in different groups using H & E staining (×200); b Articular cartilage changes observed in different groups using H & E staining (×200); c Cartilage changes observed in different groups using toluidine blue staining; (×200); d Bone destruction changes observed in different groups using H & E staining (×200); e–g showed the inflammation score, the bone destruction score and the loss of toluidine blue staining in joints respectively, calculated as described in “Methods” section. Data are represented as the mean ± SD. *, **, and ***, P < 0.05, P < 0.01, and P < 0.001, respectively, in contrast with the model control (Mod)