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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: A persistently replicating SARS-CoV-2 variant derived from an asymptomatic individual

Fig. 4

Inspection of genomic variability of SARS-CoV-2 AP66 and SARS-CoV-2 GZ69 isolates. a A colour-coded scheme of the SARS-CoV-2 genetic regions, annotated as in the reference genome NC_045512.2. ORF1ab domains where mutations in SARS-CoV-2 AP66 and SARS-CoV-2 GZ69 occurred are indicated with square brackets. Numbers indicate nucleotide (nt) positions. b Sequence variability detected in SARS-CoV-2 AP66 (upper green graph) and SARS-CoV-2 GZ69 (lower red graph). Vertical axis represents the  % of reads displaying mutations in comparison to the reference sequence NC_045512.2 at each nt position detected, as assessed by Next Generation Sequencing. Nt positions in the SARS-CoV-2 genome are reported in the horizontal axis. The central table displays nt positions where a substitution in SARS-CoV-2 AP66 and SARS-CoV-2 GZ69 in comparison to NC_045512.2 occurs (Numbers within the light green box). Nt substitutions in non-coding regions are in blue; silent substitutions are in orange; non-synonymous nt substitutions and the correspondent amino acid changes are highlighted in yellow

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