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Table 4 Differently abundant mitochondria-related proteins in the ‘ME/CFS’ PCA group compared to the ‘control’ group (P < 0.01, log10(Fold-Change) > 0.2) but also including proteins (shaded) with P < 0.05 and Fold-Change > 1.3 and < 0.75

From: A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction

Increased relative abundance proteins

P-value

Fold-change

FUN14 domain-containing protein 2

0.00023

1.91

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

0.00034

1.60

d-beta-hydroxybutyrate dehydrogenase

0.00090

2.89

Inositol-3-phosphate synthase 1

0.0025

1.82

Mitochondrial 2-oxoglutarate/malate carrier protein

0.0042

1.78

Phosphate carrier protein

0.0060

2.22

ATP synthase subunit epsilon

0.0079

1.70

Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

0.0081

2.31

Thioredoxin domain-containing protein 17

0.0065

1.58

Prohibitin

0.0079

1.40

Selenoprotein H

0.013

1.62

Endophilin-B1

0.014

1.46

Thioredoxin reductase 2

0.014

2.18

Up-regulated during skeletal muscle growth protein 5

0.014

1.79

Glutamine-dependent NAD(+) synthetase

0.014

1.53

Poly [ADP-ribose] polymerase 4

0.015

1.65

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

0.015

1.58

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11

0.016

1.64

ATP synthase subunit delta

0.017

1.78

Poly [ADP-ribose] polymerase 14

0.018

1.78

Single-stranded DNA-binding protein

0.019

1.51

Ubiquinone biosynthesis protein COQ9

0.020

1.77

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

0.020

1.76

Short-chain specific acyl-CoA dehydrogenase

0.020

1.49

Glycerol-3-phosphate dehydrogenase

0.021

1.40

2-oxoglutarate dehydrogenase

0.025

1.35

Aconitate hydratase

0.025

1.36

39S ribosomal protein L43

0.027

1.55

Cytochrome c oxidase assembly factor 6 homolog

0.028

1.47

Biogenesis of lysosome-related organelles complex 1 subunit 1

0.030

2.04

Pyruvate dehydrogenase E1 component subunit beta

0.032

1.31

BRI3-binding protein

0.033

2.27

Trifunctional enzyme subunit beta

0.034

1.40

ATP synthase subunit b

0.035

1.49

Putative transferase CAF17

0.036

1.30

Glycine–tRNA ligase

0.037

1.47

39S ribosomal protein L12, mitochondrial

0.038

1.63

Peptidyl-prolyl cis–trans isomerase NIMA-interacting 4 isoform 1

0.040

1.46

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform a precursor

0.042

2.17

Mitochondrial fission 1 protein

0.047

1.48

Decreased relative abundance proteins

P-value

Fold-Change

Isocitrate dehydrogenase [NADP], mitochondrial precursor

0.0001

0.59

Peptidyl-prolyl cis–trans isomerase F, mitochondrial precursor

0.0005

0.38

Peroxiredoxin-6

0.0081

0.66

Thiosulfate sulfurtransferase

0.0092

0.65

Choline transporter-like protein 1

0.011

0.36

39S ribosomal protein L23, mitochondrial

0.012

0.45

Mitochondrial import inner membrane translocase subunit Tim8 A isoform 1

0.012

0.47

Cytochrome c

0.013

0.56

ATP synthase mitochondrial F1 complex assembly factor 1 isoform 2 precursor

0.013

0.60

ATP-binding cassette sub-family B member 7, mitochondrial isoform 1

0.018

0.55

Dynamin-1-like protein isoform 1

0.019

0.68

Stimulator of interferon genes protein

0.036

0.61

Oxidation resistance protein 1 isoform 4

0.037

0.69

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

0.040

0.60

Glycerol kinase isoform b

0.047

0.70

CCA tRNA nucleotidyltransferase 1, mitochondrial

0.048

0.57

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Journal of Translational Medicine

ISSN: 1479-5876

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