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Table 4 Differently abundant mitochondria-related proteins in the ‘ME/CFS’ PCA group compared to the ‘control’ group (P < 0.01, log10(Fold-Change) > 0.2) but also including proteins (shaded) with P < 0.05 and Fold-Change > 1.3 and < 0.75

From: A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction

Increased relative abundance proteins P-value Fold-change
FUN14 domain-containing protein 2 0.00023 1.91
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 0.00034 1.60
d-beta-hydroxybutyrate dehydrogenase 0.00090 2.89
Inositol-3-phosphate synthase 1 0.0025 1.82
Mitochondrial 2-oxoglutarate/malate carrier protein 0.0042 1.78
Phosphate carrier protein 0.0060 2.22
ATP synthase subunit epsilon 0.0079 1.70
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific 0.0081 2.31
Thioredoxin domain-containing protein 17 0.0065 1.58
Prohibitin 0.0079 1.40
Selenoprotein H 0.013 1.62
Endophilin-B1 0.014 1.46
Thioredoxin reductase 2 0.014 2.18
Up-regulated during skeletal muscle growth protein 5 0.014 1.79
Glutamine-dependent NAD(+) synthetase 0.014 1.53
Poly [ADP-ribose] polymerase 4 0.015 1.65
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 0.015 1.58
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11 0.016 1.64
ATP synthase subunit delta 0.017 1.78
Poly [ADP-ribose] polymerase 14 0.018 1.78
Single-stranded DNA-binding protein 0.019 1.51
Ubiquinone biosynthesis protein COQ9 0.020 1.77
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 0.020 1.76
Short-chain specific acyl-CoA dehydrogenase 0.020 1.49
Glycerol-3-phosphate dehydrogenase 0.021 1.40
2-oxoglutarate dehydrogenase 0.025 1.35
Aconitate hydratase 0.025 1.36
39S ribosomal protein L43 0.027 1.55
Cytochrome c oxidase assembly factor 6 homolog 0.028 1.47
Biogenesis of lysosome-related organelles complex 1 subunit 1 0.030 2.04
Pyruvate dehydrogenase E1 component subunit beta 0.032 1.31
BRI3-binding protein 0.033 2.27
Trifunctional enzyme subunit beta 0.034 1.40
ATP synthase subunit b 0.035 1.49
Putative transferase CAF17 0.036 1.30
Glycine–tRNA ligase 0.037 1.47
39S ribosomal protein L12, mitochondrial 0.038 1.63
Peptidyl-prolyl cis–trans isomerase NIMA-interacting 4 isoform 1 0.040 1.46
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform a precursor 0.042 2.17
Mitochondrial fission 1 protein 0.047 1.48
Decreased relative abundance proteins P-value Fold-Change
Isocitrate dehydrogenase [NADP], mitochondrial precursor 0.0001 0.59
Peptidyl-prolyl cis–trans isomerase F, mitochondrial precursor 0.0005 0.38
Peroxiredoxin-6 0.0081 0.66
Thiosulfate sulfurtransferase 0.0092 0.65
Choline transporter-like protein 1 0.011 0.36
39S ribosomal protein L23, mitochondrial 0.012 0.45
Mitochondrial import inner membrane translocase subunit Tim8 A isoform 1 0.012 0.47
Cytochrome c 0.013 0.56
ATP synthase mitochondrial F1 complex assembly factor 1 isoform 2 precursor 0.013 0.60
ATP-binding cassette sub-family B member 7, mitochondrial isoform 1 0.018 0.55
Dynamin-1-like protein isoform 1 0.019 0.68
Stimulator of interferon genes protein 0.036 0.61
Oxidation resistance protein 1 isoform 4 0.037 0.69
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0.040 0.60
Glycerol kinase isoform b 0.047 0.70
CCA tRNA nucleotidyltransferase 1, mitochondrial 0.048 0.57