Fig. 4
a A schematic of the mitochondrial respiratory chain constructed by the authors to highlight the OXPHOS complexes, the major reactive oxygen species (ROS) production sites, and the ATP Synthase complex relevant to the differential expression of mitochondria-related proteins in the ME/CFS group b Highlighting differentially abundant proteins (P < 0.05, log10(Fold Change) > 0.114 and < −0.125) involved in mitochondrial function and energy metabolism. In bold are proteins with P < 0.01 and log10(Fold Change) > 0.2 and < −0.2. The green arrow represents increased relative abundance and the red arrow decreased relative abundance in the ‘ME/CFS’ PCA group, compared to controls