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Fig.8 | Journal of Translational Medicine

Fig.8

From: Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib

Fig.8

Downregulating PADI2 and Olaparib combination treatment suppresses EMT and JAK2/STAT3 signaling pathway in A2780 and SKOV3 cells. Western blotting analyses of SKOV3 and A2780 cells treated as described above. E-Cadherin, Claudin-1, Vimentin, ZEB1, N-Cadherin, phospho-Stat3 (Tyr705), phospho-Jak2 (Tyr1007), t-Stat3 and t-Jak2 levels were carried out. GAPDH served as a loading control. Fold changes of the proteins were shown on the bottom. All data are expressed as the mean ± SD of values from triplicate experiments. *P < 0.05, **P < 0.01 and ***P < 0.001 compared with control group

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