Skip to main content
Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib

Fig. 5

Downregulating PADI2 and Olaparib combination treatment attenuated the viability of ovarian cancer cells. a PADI2 knockdown inhibited A2780 and SKOV3 cell number of colony formation with and without the treatment with Olaparib. b MTT assay examined the proliferation ability of A2780 and SKOV3 cells after PADI2 knockdown with and without the treatment with Olaparib. c EdU proliferation of A2780 and SKOV3 cells after PADI2 knockdown with and without the treatment with Olaparib. A2780 and SKOV3 cells were treated as indicated and stained for EdU incorporation (green) or DAPI (blue) to highlight nuclei(Scale bar 25 μm). EdU positive A2780 and SKOV3 cells ratio was shown on the right side. All data are expressed as the mean ± SD of values from triplicate experiments. *P < 0.05, **P < 0.01 and ***P < 0.001 compared with control group

Back to article page