Table 3 Toxicity and treatment holds
| Â | Management/next dose for cisplatin | Management/next dose for pembrolizumab |
|---|---|---|
Nausea/vomiting | ||
 ≤ Grade 1 | No change in dose | No change in dose |
 Grade 2 | No change in dose | No change in dose |
 Grade 3 | Holda until < Grade 2. Resume at one dose level lower, if indicated. | No change in doseb,c |
 Grade 4 | Holda until < Grade 2. Resume at two dose levels lower. | No change in doseb,c |
Diarrhea | ||
 ≤ Grade 1 | No change in dose | No change in dose |
 Grade 2 | No change in dose | No change in dose |
 Grade 3 | Holda until < Grade 2. Resume at one dose level lower, if indicated | No change in doseb,c |
 Grade 4 | Holda until < Grade 2. Resume at two dose levels lower | No change in doseb,c |
Neutropenia | ||
 ≤ Grade 1 | No change in dose | No change in dose |
 Grade 2 | No change in dose | No change in dose |
 Grade 3 | No change in dose | No change in dose |
 Grade 4 | Holdd until < Grade 3. Resume at current dose. | Hold until ≤ Grade 2 |
Thrombocytopenia | ||
 ≤ Grade 1 | No change in dose | No change in dose |
 Grade 2 | No change in dose | No change in dose |
 Grade 3 | Holdd until < Grade 2. Resume at same dose level | No change in dose |
 Grade 4 | Holdd until < Grade 2. Resume at same dose level | Hold until ≤ Grade 2 |