Cycle 1 criteria | Subsequent cycles |
---|---|
Absolute neutrophil count ≥ 1500/mcL Platelets ≥ 100,000/mcL Hemoglobin ≥ 9 g/dL Total bilirubin ≤ 1.5 × institutional upper limit of normal AST (SGOT)/ALT (SGPT) ≤ 2.5 × institutional upper limit of normal Creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 50 mL/min for subjects with creatinine levels above institutional ULN All toxicities of previous therapy (aside from alopecia) must have resolved to ≤ grade 1 ECOG performance of 0 or 1 No evidence of life-threatening medical problems | Absolute neutrophil count ≥ 500/mcL Platelets ≥ 50,000/mcL AST (SGOT)/ALT (SGPT) ≤ 2.5  ×  institutional upper limit of normal Creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 50 mL/min for subjects with creatinine levels above institutional ULN All toxicities of previous cycles must have resolved to ≤ grade 2 ECOG performance of 0 to 2 No evidence of life-threatening medical problems |