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Table 4 Frequencies of the single alleles and allelic combinations of the HLA-A, -B, -C, -DRB1 loci of the haplotype HLA-A*01:01g-B*08:01g-C*07:01g-DRB1*03:01g in the Italian population

From: Correlation of the two most frequent HLA haplotypes in the Italian population to the differential regional incidence of Covid-19

Frequency (%)

Regions

HLA-A*01:01g

HLA-B*08:01g

HLA-DRB1*03:01g

HLA-A*01:01g- B*08:01g

HLA-A*01:01g-C*07:01g

HLA-A*01:01g-DRB1*03:01g

HLA-B*08:01g-C*07:01g

Italy

11.53

5.76

9.47

3.45

4.63

2.89

5.16

Abruzzo

11.40

4.34

7.24

2.59

3.73

2.57

3.73

Basilicata

10.28

2.92

7.21

1.33

3.26

1.45

1.35

Calabria

10.37

3.06

5.95

1.38

3.14

0.95

2.34

Campania

11.27

3.97

7.76

1.87

3.62

1.70

3.04

Emilia Romagna

11.84

6.40

8.94

3.61

4.56

2.91

5.76

Friuli Venezia Giulia

11.42

6.49

10.73

4.09

5.25

3.51

5.86

Lazio

11.10

4.70

8.68

2.51

3.66

2.52

4.02

Liguria

12.50

6.33

9.37

3.91

5.03

3.45

5.75

Lombardia

11.84

6.32

9.42

3.74

4.90

3.14

5.78

Marche

12.41

5.22

7.89

3.11

4.49

3.11

4.75

Molise

10.22

3.91

7.17

2.39

3.70

2.61

3.48

Piemonte

11.53

5.79

9.04

3.61

4.68

2.95

5.22

Puglia

11.75

3.56

6.84

1.90

3.46

1.67

2.78

Sardegna

5.33

2.53

21.20

1.36

1.95

1.38

2.26

Sicilia

11.34

3.96

7.02

2.02

3.98

1.80

3.00

Toscana

11.98

6.44

9.78

3.95

5.14

3.36

5.74

Trentino Alto Adige

12.70

8.23

10.67

5.84

6.76

4.76

7.82

Umbria

11.48

6.04

10.12

2.69

3.62

2.84

4.92

Valle D’Aosta

9.02

5.37

7.80

1.22

2.44

1.71

4.39

Veneto

12.45

7.30

10.23

4.82

5.91

3.90

6.87

Frequency (%)

Regions

HLA-B*08:01g-DRB1*03:01g

HLA-C*07:01g-DRB1*03:01g

HLA-A*01:01g-B*08:01g-C*07:01g

HLA-A*01:01g-B*08:01g-DRB1*03:01g

HLA-A*01:01g-C*07:01g-DRB1*03:01g

HLA-B*08:01g-C*07:01g-DRB1*03:01g

Italy

4.20

4.30

3.40

2.57

2.58

3.80

Abruzzo

3.11

3.21

2.59

2.08

2.08

3.03

Basilicata

1.77

2.20

1.33

1.21

2.08

0.44

Calabria

1.86

2.35

1.36

0.82

2.08

0.60

Campania

2.95

3.11

1.76

1.47

1.51

2.35

Emilia Romagna

4.58

4.65

3.57

2.66

2.67

4.22

Friuli Venezia Giulia

4.97

4.78

4.07

3.15

3.18

4.56

Lazio

3.59

3.78

2.47

2.03

2.09

3.17

Liguria

4.67

4.86

3.88

3.04

3.11

4.33

Lombardia

4.74

4.75

3.68

2.87

2.87

4.37

Marche

3.86

4.05

3.08

2.58

2.69

3.58

Molise

2.61

2.83

2.39

1.74

1.74

2.39

Piemonte

4.16

4.31

3.57

2.66

2.70

3.79

Puglia

2.43

2.50

1.83

1.37

1.32

1.85

Sardegna

1.84

3.32

1.29

1.14

1.11

1.60

Sicilia

2.75

2.87

1.92

1.53

1.49

2.15

Toscana

4.74

4.65

3.88

3.09

3.11

4.38

Trentino Alto Adige

6.23

6.19

5.79

4.50

4.47

6.01

Umbria

4.08

3.41

2.47

2.39

2.17

3.41

Valle D’Aosta

3.90

3.90

1.22

1.22

1.22

2.93

Veneto

5.38

5.45

4.78

3.50

3.52

5.09