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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients

Fig. 6

MKK3 increases the tumor aggressiveness in Black/African American patients with triple-negative breast cancer. a Representative histological image of the basal-like BRCA tumor from a Black/African American patient (TCGA patient id: TCGA-A2-A3XU) with the overexpressed MKK3. b Representative histological image of the basal-like BRCA tumor from a Black/African American patient (TCGA patient id: TCGA-E2-A14X) with a normal level of MKK3 expression. c The tumor to stroma ratio calculated for basal-like BRCA tumor samples from Black/African American patients correlates positively with the expression of MKK3 and MYC and negatively with the expression of p38. The Spearman correlation coefficients (R), p-values, and the false discovery rate adjusted q-values are indicated. d MKK3 and MYC expression, but not p38 expression, correlates positively with the increased size and decreased the number of tumor nests per unit area (i.e. “fusion” into large infiltrative nests with less intervening stroma). The Spearman correlation coefficients (R), p-values, and the false discovery rate adjusted q-values are indicated

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