Fig. 9
From: MiR-199a-3p/5p participated in TGF-β and EGF induced EMT by targeting DUSP5/MAP3K11 in pterygium
MiR-199a-3p, miR-199a-5p, DUSP5 and MAP3K11 expressions in pterygium. a, b Both miR-199a-3p (****p < 0.0001) and miR-199a-5p (****p < 0.0001) were upregulated in pterygium samples (n = 234) compared with control conjunctiva tissues (n = 29). c, d The relative expression of DUSP5 mRNA was downregulated in pterygium samples (n = 196) compared with control conjunctiva tissues (n = 15) (***p < 0.001). The relative expression of MAP3K11 mRNA was downregulated in pterygium samples (n = 79) compared with control conjunctiva tissues (n = 11) (***p < 0.001). e DUSP5 and MAP3K11 expressions were analyzed by western blot in pterygium samples and control conjunctiva tissues. f, g The relationship between DUSP5 mRNA and miR-199a-3p expressions, MAP3K11 mRNA and miR-199a-5p expressions were detected by Spearman’s correlation analysis, and both of them significantly showed a negative correlation (R = -0.1586, P = 0.0249; R = -0.3237, p = 0.0024)