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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: MiR-199a-3p/5p participated in TGF-β and EGF induced EMT by targeting DUSP5/MAP3K11 in pterygium

Fig. 8

Inhibition on miR-199a-3p and miR-199a-5p alleviates the EMT promoted by DUSP5 and MAP3K11 in induced HCEs. HCEs were induced with TGF-β (10 nM) and EGF (20 nM) for 7 days, and subsequently transfected with pCMV-myc-DUSP5 (or pCMV-myc-MAP3K11) and pCMV-myc, miR-199a-3p (miR-199a-5p) inhibitor/inhibitor NC and miR-199a-3p (miR-199a-5p) mimic/mimic NC. Un-transfected HCEs with or without inducement were also included. a, b The migration ability of HCE was measured by transwell assay (**p < 0.01, ***p < 0.001). c, d The EMT progression of HCE was measured as 3 EMT markers by western blot (*p < 0.05, **p < 0.01, ***p < 0.001)

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