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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: MiR-199a-3p/5p participated in TGF-β and EGF induced EMT by targeting DUSP5/MAP3K11 in pterygium

Fig. 1

Differential expressed miRNAs in pterygium. a The log scales of most miRNAs expression in pterygium tissues were found from -1 to 1. X-axis indicates the log scale of miRNA expression in control conjunctiva and pterygium tissues. Negative scale indicates downregulation, and positive scale indicates overexpression. b The volcano plot of the microarray with the criteria of lg (FC) > 1 and p value < 0.05. The green nodes presented the downregulated miRNAs and the red nodes presented the upregulated miRNAs. c The heat map showed the expression levels of miRNAs which were indicated on a colour gradation scale from low expression (blue) to high expression (red) in pterygium (P1, P2, P3) and control conjunctiva (C1, C2, C3) groups. d The relative expression of six validated miRNAs in pterygium. MiR-30a-5p (p = 0.043) and miR-199a-5p (p = 0.002) were up-regulated in pterygium samples (n = 55) compared with control conjunctiva tissues (n = 11), and miR-143-5p (p < 0.0001), miR-486-3p (p < 0.0001), miR-199a-3p (p = 0.001) were up-regulated in pterygium samples (n = 40) compared with control conjunctiva tissues (n = 6). The verification result of miR-675-5p (p = 0.613) was inconsistent with the chip

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