Skip to main content

Table 1 Demographic, clinical characteristics and FCGRIIB rs1050501 genotypes distribution of subjects enrolled in the study

From: Relation between FCGRIIB rs1050501 and HSV-1 specific IgG antibodies in Alzheimer’s disease

  AD MCI Healthy controls
 N. 225 93 201
 Gender (M:F) 81:144 49:44 80:121
 Age, years 76.8 ± 6.4 75.0 ± 6.4 74.8 ± 10.3
 MMSE 18.7 ± 5.5* 24.8 ± 2.9
 APOE ε-4 carriers (%) 52.0#,° 39.5# 17.7
 HSV-1 IgG (AI)a 8.9; 7.1–10.1** 8.8; 6.7–11.1*** 7.4 6.0–8.5
 HSV-1 Avidity index (%)a 87.9; 79.8–95.0 91.4; 85.7–97.6 90.1; 81.3–95.6
 FCGRIIB rs1050501 genotypes (%)
  TT 78.7 75.3 77.1
  CT 19.1 22.6 20.4
  CC 2.2 2.1 2.5
  1. Data are reported as mean ± standard deviation or as median; Interquartile range
  2. AD Alzheimer’s disease, MCI Mild Cognitive Impairment, M male, F female, MMSE mini mental state evaluation, APOE Apolipoprotein E, AI antibody index
  3. *p < 0.0001 compared to MCI
  4. #p < 0.0001 compared to HC
  5. °p = 0.046 compared to MCI
  6. **p = 0.001 compared to HC
  7. ***p = 0.0077 compared to HC
  8. aperformed on a subgroup of 69 AD 52 MCI and 49 HC