Fig. 4

Interaction diagrams for the six residuals from seven ACE2 missense variants. a Interactions of Gly211Arg, b interactions of Asp206Gly, c interactions of Arg219Cys/His, d interactions of Lys341Arg, e interactions of Ile468Val and f interactions of Ser547Cys. Hydrogen bonds are depicted as blue dots. Π-interactions are depicted as yellow arrows. Hydrophobic interactions are shown as grey arrows. Water molecules from water-bridge are displayed as red spheres