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Table 3 The relationship between 4-lncRNA signature and Clinical characteristics in the three NSCLC patient cohorts

From: Identification of a 4-lncRNA signature predicting prognosis of patients with non-small cell lung cancer: a multicenter study in China

Characteristics Discovery cohort (N = 194) Validation cohort (N = 172) Independent cohort (N = 73)
Low-risk High-risk P value Low-risk High-risk P value Low-risk High-risk P value
n (%) n (%) n (%) n (%) n (%) n (%)
Age
 ≥ 60 52 (53.6) 49 (50.5) 0.706 49 (57.0) 46 (53.5) 0.816 19 (51.4) 21 (58.3) 0.493
 < 60 45 (46.4) 48 (49.5)   37 (43.0) 40 (46.5)   18 (48.6) 15 (41.7)  
Gender
 Male 82 (84.5) 72 (74.2) 0.269 67 (77.9) 69 (80.2) 0.374 29 (78.4) 23 (63.9) 0.290
 Female 15 (15.5) 25 (25.8)   19 (22.1) 17 (19.8)   8 (21.6) 13 (36.1)  
TNM stage
 I 46 (47.4) 41 (42.3) 0.637 39 (45.3) 35 (40.7) 0.702 13 (35.1) 10 (27.8) 0.518
 II 11 (11.3) 21 (21.6)   18 (21.0) 16 (18.6)   8 (21.6) 12 (33.3)  
 III 40 (41.2) 35 (36.1)   29 (33.7) 35 (40.7)   16 (43.2) 14 (38.9)  
Histological type
 ADC 55 (56.7) 40 (41.2) 0.304 39 (45.3) 50 (58.1) 0.297 25 (67.6) 22 (61.1) 0.451
 SCC 39 (40.2) 49 (50.5)   40 (46.5) 36 (41.9)   12 (32.4) 14 (38.9)  
 ADC/SCC 3 (3.1) 8 (8.3)   7 (8.2) 0 (0.0)   0 (0.0) 0 (0.0)  
Tumor size (cm)
 < 5 59 (60.8) 49 (50.5) 0.332 46 (53.5) 51 (59.3) 0.573 13 (35.1) 18 (50.0) 0.197
 ≥ 5 38 (39.2) 48 (49.5)   40 (46.5) 35 (40.7)   24 (64.9) 18 (50.0)  
Differentiation
 Well/moderate 58 (59.8) 68 (70.1) 0.402 44 (51.2) 61 (70.9) 0.203 19 (51.4) 24 (66.7) 0.310
 Poor 39 (40.2) 29 (29.9)   42 (48.8) 25 (29.1)   18 (48.6) 12 (33.3)  
Lymph metastasis
 No 47 (48.5) 58 (59.8) 0.257 39 (45.3) 42 (48.8) 0.574 21 (56.8) 24 (66.7) 0.297
 Yes 50 (51.5) 39 (40.2)   47(54.7) 44 (51.2)   16 (43.2) 12 (33.3)  
Smoking history
 No 36 (37.1) 43 (44.3) 0.503 29 (33.7) 33 (38.4) 0.692 15 (40.5) 18 (50.0) 0.307
 Yes 61 (62.9) 54 (55.7)   57 (66.3) 53 (61.6)   22 (59.5) 18 (50.0)  
Fam. cancer hist.
 No 84 (86.6) 77 (79.3) 0.396 73 (75.3) 78 (90.7) 0.417 36 (97.3) 35 (97.2) 0.664
 Yes 13 (13.4) 20 (20.7)   13 (13.4) 8 (9.3)   1 (2.7) 1 (2.8)  
  1. Fam. cancer hist. Family cancer history