|
Characteristics
|
Discovery cohort (N = 194)
|
Validation cohort (N = 172)
|
Independent cohort (N = 73)
|
|---|
|
Low-risk
|
High-risk
|
P value
|
Low-risk
|
High-risk
|
P value
|
Low-risk
|
High-risk
|
P value
|
|---|
|
n (%)
|
n (%)
|
n (%)
|
n (%)
|
n (%)
|
n (%)
|
|---|
|
Age
|
|
≥ 60
|
52 (53.6)
|
49 (50.5)
|
0.706
|
49 (57.0)
|
46 (53.5)
|
0.816
|
19 (51.4)
|
21 (58.3)
|
0.493
|
|
< 60
|
45 (46.4)
|
48 (49.5)
| |
37 (43.0)
|
40 (46.5)
| |
18 (48.6)
|
15 (41.7)
| |
|
Gender
|
|
Male
|
82 (84.5)
|
72 (74.2)
|
0.269
|
67 (77.9)
|
69 (80.2)
|
0.374
|
29 (78.4)
|
23 (63.9)
|
0.290
|
|
Female
|
15 (15.5)
|
25 (25.8)
| |
19 (22.1)
|
17 (19.8)
| |
8 (21.6)
|
13 (36.1)
| |
|
TNM stage
|
|
I
|
46 (47.4)
|
41 (42.3)
|
0.637
|
39 (45.3)
|
35 (40.7)
|
0.702
|
13 (35.1)
|
10 (27.8)
|
0.518
|
|
II
|
11 (11.3)
|
21 (21.6)
| |
18 (21.0)
|
16 (18.6)
| |
8 (21.6)
|
12 (33.3)
| |
|
III
|
40 (41.2)
|
35 (36.1)
| |
29 (33.7)
|
35 (40.7)
| |
16 (43.2)
|
14 (38.9)
| |
|
Histological type
|
|
ADC
|
55 (56.7)
|
40 (41.2)
|
0.304
|
39 (45.3)
|
50 (58.1)
|
0.297
|
25 (67.6)
|
22 (61.1)
|
0.451
|
|
SCC
|
39 (40.2)
|
49 (50.5)
| |
40 (46.5)
|
36 (41.9)
| |
12 (32.4)
|
14 (38.9)
| |
|
ADC/SCC
|
3 (3.1)
|
8 (8.3)
| |
7 (8.2)
|
0 (0.0)
| |
0 (0.0)
|
0 (0.0)
| |
|
Tumor size (cm)
|
|
< 5
|
59 (60.8)
|
49 (50.5)
|
0.332
|
46 (53.5)
|
51 (59.3)
|
0.573
|
13 (35.1)
|
18 (50.0)
|
0.197
|
|
≥ 5
|
38 (39.2)
|
48 (49.5)
| |
40 (46.5)
|
35 (40.7)
| |
24 (64.9)
|
18 (50.0)
| |
|
Differentiation
|
|
Well/moderate
|
58 (59.8)
|
68 (70.1)
|
0.402
|
44 (51.2)
|
61 (70.9)
|
0.203
|
19 (51.4)
|
24 (66.7)
|
0.310
|
|
Poor
|
39 (40.2)
|
29 (29.9)
| |
42 (48.8)
|
25 (29.1)
| |
18 (48.6)
|
12 (33.3)
| |
|
Lymph metastasis
|
|
No
|
47 (48.5)
|
58 (59.8)
|
0.257
|
39 (45.3)
|
42 (48.8)
|
0.574
|
21 (56.8)
|
24 (66.7)
|
0.297
|
|
Yes
|
50 (51.5)
|
39 (40.2)
| |
47(54.7)
|
44 (51.2)
| |
16 (43.2)
|
12 (33.3)
| |
|
Smoking history
|
|
No
|
36 (37.1)
|
43 (44.3)
|
0.503
|
29 (33.7)
|
33 (38.4)
|
0.692
|
15 (40.5)
|
18 (50.0)
|
0.307
|
|
Yes
|
61 (62.9)
|
54 (55.7)
| |
57 (66.3)
|
53 (61.6)
| |
22 (59.5)
|
18 (50.0)
| |
|
Fam. cancer hist.
|
|
No
|
84 (86.6)
|
77 (79.3)
|
0.396
|
73 (75.3)
|
78 (90.7)
|
0.417
|
36 (97.3)
|
35 (97.2)
|
0.664
|
|
Yes
|
13 (13.4)
|
20 (20.7)
| |
13 (13.4)
|
8 (9.3)
| |
1 (2.7)
|
1 (2.8)
| |
- Fam. cancer hist. Family cancer history
