Skip to main content

Table 3 Success rate of ex vivo propagated DTCs derived from the BM of SK-BR-3-transplanted HTM and TM

From: A novel rabbit derived anti-HER2 antibody with pronounced therapeutic effectiveness on HER2-positive breast cancer cells in vitro and in humanized tumor mice (HTM)

 

Control

B100

p-value (control vs. B100)

Trast

p-value (control vs. Trast)

Pert

p-value (control vs. Pert)

HTM

7/8

0/5

0.0047

3/3

1

1/4

0.067

TM

2/4

0/4

0.4286

nd

–

n. d.

–

  1. Single cells isolated from the femur of SK-BR-3-transplanted HTM and TM were cultured for several weeks to expand DTCs. The number of animals with successfully expanded DTC cultures of the total number of all tested samples (n/n) is indicated. Statistical differences were calculated using the two-sided Fisher’s exact test and significances are typed italic
  2. nd not done