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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: A novel rabbit derived anti-HER2 antibody with pronounced therapeutic effectiveness on HER2-positive breast cancer cells in vitro and in humanized tumor mice (HTM)

Fig. 5

Antibody treatment responsiveness from ex vivo cultured tumor cells isolated from the BM and peritoneum (PTC) of HTM and TM. a Percentage of HER2+ tumor cells in single cell suspension isolated from the BM of HTM measured by flow cytometry. SPF reduction of trastuzumab treated SK-BR-3 cell cultures in comparison to ex vivo trastuzumab treated tumor cells isolated from BM (b) and peritoneum (c) of HTM and TM. Each symbol represents one mouse. Data are shown as mean ± SEM and no significances were detectable using Tukey‘s multiple comparison test. Trast, trastuzumab; Pert, pertuzumab

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