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Table 1 KEGG pathways enrichment in the list of host factors interacting with viral proteins for SARS-CoV-2 (a), highly pathogenic hCoVs (b) and all coronaviruses (c)

From: The current landscape of coronavirus-host protein–protein interactions

Kegg pathway (Term) Count % p-value Fold enrichment Benjamini p-value
a—Kegg pathways enrichment in SARS-CoV-2 host protein targets (n = 333)
Protein processing in endoplasmic reticulum 13 4 8.80E−05 4 1.70E−02
RNA transport 12 3.7 4.40E−04 3.6 4.10E−02
b—Kegg pathways enrichment in highly pathogenic hCoVs host protein targets (n = 483)
RIG-I-like receptor signaling pathway 14 3 1.30E−07 6.6 3.00E−05
NF-kappa B signaling pathway 13 2.8 1.10E−05 4.9 8.00E−04
RNA transport 19 4.1 4.10E−06 3.6 4.50E−04
Protein processing in endoplasmic reticulum 18 3.9 1.30E−05 3.5 7.20E−04
Epstein-Barr virus infection 13 2.8 3.10E−04 3.5 1.10E−02
Influenza A 18 3.9 1.90E−05 3.4 8.40E−04
Measles 13 2.8 6.80E−04 3.2 2.10E−02
c—Kegg pathways enrichment in Coronaviruses host protein targets (n = 1140)
Ribosome 59 5.4 9.0E−31 5.8 2.3E−28
RIG-I-like receptor signaling pathway 16 1.5 1.60E−04 3.1 5.60E−03
Protein processing in endoplasmic reticulum 37 3.4 5.20E−09 2.9 6.60E−07
RNA transport 33 3 1.00E−06 2.6 6.30E−05
Endocytosis 43 3.9 1.30E−07 2.4 1.10E−05
Spliceosome 24 2.2 1.10E−04 2.4 4.70E−03
Phagosome 26 2.4 1.00E−04 2.3 5.30E−03