Table 1 KEGG pathways enrichment in the list of host factors interacting with viral proteins for SARS-CoV-2 (a), highly pathogenic hCoVs (b) and all coronaviruses (c)
From: The current landscape of coronavirus-host protein–protein interactions
Kegg pathway (Term) | Count | % | p-value | Fold enrichment | Benjamini p-value |
|---|---|---|---|---|---|
a—Kegg pathways enrichment in SARS-CoV-2 host protein targets (n = 333) | |||||
Protein processing in endoplasmic reticulum | 13 | 4 | 8.80E−05 | 4 | 1.70E−02 |
RNA transport | 12 | 3.7 | 4.40E−04 | 3.6 | 4.10E−02 |
b—Kegg pathways enrichment in highly pathogenic hCoVs host protein targets (n = 483) | |||||
RIG-I-like receptor signaling pathway | 14 | 3 | 1.30E−07 | 6.6 | 3.00E−05 |
NF-kappa B signaling pathway | 13 | 2.8 | 1.10E−05 | 4.9 | 8.00E−04 |
RNA transport | 19 | 4.1 | 4.10E−06 | 3.6 | 4.50E−04 |
Protein processing in endoplasmic reticulum | 18 | 3.9 | 1.30E−05 | 3.5 | 7.20E−04 |
Epstein-Barr virus infection | 13 | 2.8 | 3.10E−04 | 3.5 | 1.10E−02 |
Influenza A | 18 | 3.9 | 1.90E−05 | 3.4 | 8.40E−04 |
Measles | 13 | 2.8 | 6.80E−04 | 3.2 | 2.10E−02 |
c—Kegg pathways enrichment in Coronaviruses host protein targets (n = 1140) | |||||
Ribosome | 59 | 5.4 | 9.0E−31 | 5.8 | 2.3E−28 |
RIG-I-like receptor signaling pathway | 16 | 1.5 | 1.60E−04 | 3.1 | 5.60E−03 |
Protein processing in endoplasmic reticulum | 37 | 3.4 | 5.20E−09 | 2.9 | 6.60E−07 |
RNA transport | 33 | 3 | 1.00E−06 | 2.6 | 6.30E−05 |
Endocytosis | 43 | 3.9 | 1.30E−07 | 2.4 | 1.10E−05 |
Spliceosome | 24 | 2.2 | 1.10E−04 | 2.4 | 4.70E−03 |
Phagosome | 26 | 2.4 | 1.00E−04 | 2.3 | 5.30E−03 |