Table 1 Clinical characteristics between successful and failed PDX engraftment
N = 139 | PDX success | PDX failure | p value |
|---|---|---|---|
Age(years) Mean | 66.4 ± 6.8 | 64.8 ± 8.9 | 0.244* |
Gender | |||
 Male | 60 (96.8%) | 73 (94.8%) | 0.692** |
 Female | 2 (3.2%) | 4(5.2%) | |
Smoking status | |||
 Former or current | 61 (98.4%) | 76 (98.7%) | 1.000** |
 Never | 1 (1.6%) | 1 (1.3%) | |
Preoperative Chemotherapy | |||
 Yes | 3 (4.8%) | 13 (16.9%) | 0.033** |
 No | 59 (95.2%) | 64 (83.1%) | |
pTNM stage (7th) | |||
 I | 18 (29.0%) | 28 (36.4%) | 0.348** |
 II | 29 (46.8%) | 25 (32.5%) | |
 III | 14 (22.6%) | 23 (29.9%) | |
 IV | 1 (1.6%) | 1 (1.3%) | |
Tumor size | |||
  < 3 cm | 13 (21.0%) | 25 (32.5%) | 0.204** |
 3 <  < 5 | 21 (33.9%) | 27 (35.1%) | |
 5 <  < 7 | 21 (33.9%) | 22 (28.6%) | |
 7 >  | 7 (11.3%) | 3 (3.9%) | |
Differentiation | |||
 Well | 1 (1.6%) | 1 (1.1%) | 1.000** |
 Moderate | 47 (75.8%) | 58 (76.3%) | |
 Poor | 14 (22.6%) | 17 (22.4%) | |
Recurrence | |||
 Yes | 14 (22.6%) | 14 (18.2%) | 0.671** |
 No | 48 (77.4%) | 63 (81.8%) | |
Vascular invasion | |||
 Yes | 8 (12.9%) | 8 (10.4%) | 0.399** |
 No | 54 (87.1%) | 69(92.2%) | |
Perineural invasion | |||
 Yes | 8 (12.9%) | 6 (7.8%) | 0.399** |
 No | 54 (87.1%) | 71(92.2%) | |
Lymphatic invasion | |||
 Yes | 22 (35.5%) | 21 (27.3%) | 0.357** |
 No | 40 (64.5%) | 56 (72.7%) | |
Visceral pleural invasion | |||
 PL0 | 46 (74.2%) | 61 (81.3%) | 0.599** |
 PL1 | 1 (1.6%) | 2 (2.7%) | |
 PL2 | 6 (9.7%) | 6 (8.0%) | |
 PL3 | 9 (14.5%) | 6 (8.0%) | |