Table 5 The KEGG pathway enrichment analysis of genes in each module
From: Identifying the pattern of immune related cells and genes in the peripheral blood of ischemic stroke
KEGG term ID | Term description | FDR |
|---|---|---|
Black module | ||
 hsa04668 | TNF signaling pathway | 0.0029 |
 hsa04610 | Complement and coagulation cascades | 0.0065 |
 hsa04621 | NOD-like receptor signaling pathway | 0.0068 |
Blue module (top 10) | ||
 hsa04142 | Lysosome | 0.0015 |
 hsa04670 | Leukocyte transendothelial migration | 0.0015 |
 hsa04380 | Osteoclast differentiation | 0.0078 |
 hsa05152 | Tuberculosis | 0.0078 |
 hsa00052 | Galactose metabolism | 0.0079 |
 hsa05140 | Leishmaniasis | 0.0136 |
 hsa04140 | Autophagy—animal | 0.0233 |
 hsa04666 | Fc gamma R-mediated phagocytosis | 0.0286 |
 hsa05161 | Hepatitis B | 0.032 |
 hsa05322 | Systemic lupus erythematosus | 0.032 |
Green module | ||
 hsa04610 | Complement and coagulation cascades | 0.0028 |
 hsa05133 | Pertussis | 0.0132 |
 hsa04010 | MAPK signaling pathway | 0.0394 |
Pink module | ||
 hsa05322 | Systemic lupus erythematosus | 0.0161 |
Purple module | ||
 hsa04145 | Phagosome | 0.00051 |
 hsa00380 | Tryptophan metabolism | 0.0024 |
 hsa00340 | Histidine metabolism | 0.0176 |
 hsa04066 | HIF-1 signaling pathway | 0.0176 |
 hsa04640 | Hematopoietic cell lineage | 0.0176 |
 hsa04216 | Ferroptosis | 0.0327 |
 hsa00480 | Glutathione metabolism | 0.0396 |
 hsa04979 | Cholesterol metabolism | 0.0396 |
Turquoise module (top 10) | ||
 hsa05167 | Kaposi’s sarcoma-associated herpesvirus infection | 2.06E−05 |
 hsa05161 | Hepatitis B | 4.52E−05 |
 hsa05162 | Measles | 0.00013 |
 hsa05164 | Influenza A | 0.00013 |
 hsa05321 | Inflammatory bowel disease (IBD) | 0.00024 |
 hsa05140 | Leishmaniasis | 0.00042 |
 hsa04620 | Toll-like receptor signaling pathway | 0.00045 |
 hsa04012 | ErbB signaling pathway | 0.00088 |
 hsa04660 | T cell receptor signaling pathway | 0.0019 |
 hsa04917 | Prolactin signaling pathway | 0.0019 |
Yellow module | ||
 hsa05340 | Primary immunodeficiency | 4.86E−05 |
 hsa04060 | Cytokine-cytokine receptor interaction | 0.00079 |
 hsa04662 | B cell receptor signaling pathway | 0.00079 |
 hsa04640 | Hematopoietic cell lineage | 0.0018 |
 hsa04650 | Natural killer cell mediated cytotoxicity | 0.006 |
 hsa04659 | Th17 cell differentiation | 0.0143 |
 hsa04660 | T cell receptor signaling pathway | 0.0143 |
 hsa04514 | Cell adhesion molecules (CAMs) | 0.0455 |
 hsa04658 | Th1 and Th2 cell differentiation | 0.0493 |