Identifying the pattern of immune related cells and genes in the peripheral blood of ischemic stroke

Table 3 The real hub genes in the co-expression and PPI networks

GeneSymbol	ModuleColor	GS.disease state	p.GS. disease state	MM.of related module	p.MM.of related module
TLR8	Turquoise	0.435661339	4.14E−10	0.871990002	1.33E−59
PTEN	Turquoise	0.428731523	8.34E−10	0.874600844	2.22E−60
IFNAR1	Turquoise	0.407160397	6.68E−09	0.818666737	1.12E−46
CCR7	Yellow	− 0.41442059	3.37E−09	0.810615379	4.24E−45
IL7R	Yellow	− 0.31537227	1.04E−05	0.816302419	3.31E−46
SLAMF1	Yellow	-0.333846288	2.84E−06	0.808174198	1.23E−44
TIMP2	Blue	0.447586714	1.20E−10	0.899305925	1.00E−68
CANT1	Blue	0.390141685	3.12E−08	0.82537424	4.68E−48
PAK1	Blue	0.501249842	2.36E−13	0.804602912	5.74E−44
ATG7	Blue	0.432671718	5.61E−10	0.802242306	1.56E−43
NCF4	Blue	0.293300473	4.41E−05	0.807809113	1.45E−44
ITGAM	Blue	0.541718688	9.94E−16	0.811555078	2.80E−45
WAS	Blue	0.479687326	3.29E−12	0.866722618	4.37E−58
MYD88	Blue	0.447728134	1.18E−10	0.80773727	1.49E−44
MAPK1	Blue	0.430201337	7.20E−10	0.864080663	2.39E−57
FGR	Blue	0.402714638	1.01E−08	0.834484479	5.05E−50

TLR toll like receptor 8, PTEN phosphatase and tensin homolog, IFNAR1 interferon alpha and beta receptor subunit 1, CCR7 C–C motif chemokine receptor 7, IL7R interleukin 7 receptor, SLAMF1 signaling lymphocytic activation molecule family member 1, TIMP2 tissue inhibitor of metalloproteinases-2, CANT1 calcium activated nucleotidase 1, PAK1 p21 (RAC1) activated kinase 1, ATG7 autophagy related 7, NCF4 neutrophil cytosolic factor 4, ITGAM integrin subunit alpha M, WAS WASP actin nucleation promoting factor, MYD88 MYD88 innate immune signal transduction adaptor, MAPK1 mitogen-activated protein kinase 1, FGR proto-oncogene, Src family tyrosine kinase, FGR

ISSN: 1479-5876