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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system

Fig. 6

Effect of injection volume on the CNS distribution and pharmacology of an ASO specific to the MAPT gene. a Graphs of the tissue concentrations (µg/g tissue) of the MAPT ASO in the lumbar and thoracic spinal cord, and frontal cortex for the animals treated with low (0.8 mL, gray) or high (2.0 mL, red) dose volume. b Graphs for the MAPT mRNA expression for the low (gray) versus high (red) volume treatments as a percentage of the vehicle treated (black) animals. At the top of each graph is the P value for the comparison of the low versus high volume treatment as calculated with two tailed Welch’s T-test. A star (*) designates a P value less than 0.05. Data is depicted as individual values with horizontal bar depicting the mean value for the group

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