Fig. 6From: Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous systemEffect of injection volume on the CNS distribution and pharmacology of an ASO specific to the MAPT gene. a Graphs of the tissue concentrations (µg/g tissue) of the MAPT ASO in the lumbar and thoracic spinal cord, and frontal cortex for the animals treated with low (0.8 mL, gray) or high (2.0 mL, red) dose volume. b Graphs for the MAPT mRNA expression for the low (gray) versus high (red) volume treatments as a percentage of the vehicle treated (black) animals. At the top of each graph is the P value for the comparison of the low versus high volume treatment as calculated with two tailed Welch’s T-test. A star (*) designates a P value less than 0.05. Data is depicted as individual values with horizontal bar depicting the mean value for the groupBack to article page