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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: A modular framework for the development of targeted Covid-19 blood transcript profiling panels

Fig. 6

High resolution annotation framework supporting the curation and interpretation of Covid-19 module sets. This series of screenshots shows the content of the interactive presentations that have been established to provide curators with access to detailed annotations regarding modules forming a given aggregate, its constitutive modules and targets that have been selected for inclusion in transcript panels. Links to interactive presentations and resources mentioned below are available in Table 3. a Module aggregate-level information. This section displays patterns of transcript abundance across the modules forming a given aggregate, as well as the degree of association of this aggregate with the severity of RSV disease. Plots used to populate this section were generated using three web applications, including one that was developed in support of this work that compiles the Covid-19 blood transcriptional data available to date. The other two applications were developed as part of a previous study to generate plots for the reference disease cohorts and RSV severity association plots [47]. b Module-level information. This section includes, for a given module, reports from functional profiling tools as well as patterns of transcript abundance across the genes forming the module. Drug targeting profiles were added to provide another level of information. c Gene-centric information. The information includes curated pathways from the literature, articles and reports from public resources. Gene-centric transcriptional profiles that are available via gene expression browsing applications deployed by our group are also captured and used for context (GXB). A synthesis of the information gathered by expert curation and potential relevance to SARS-Cov-2 infection can also be captured and presented here

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