Fig. 4

Delineation of sets of Covid-19 relevant A28 modules. a Transcript abundance profiles of A28 modules in Covid-19 patients. This heatmap shows the abundance levels for transcripts forming modules belonging to aggregate A28 (rows), across three Covid-19 patients (P1–P3) relative to one uninfected control subject (columns). The data are expressed as the proportion of constitutive transcripts in each module being significantly increased (red circles) or decreased (blue circles). b Transcript abundance profiles of A28 modules in reference disease cohorts. The top heatmap shows the abundance levels for transcripts forming modules belonging to aggregate A28 (rows), across 16 reference patient cohorts (columns). The bottom heatmaps show changes in abundance across individuals constituting the two relevant patient cohorts, including pediatric patients with severe influenza or RSV infection and adult patients with sepsis