From: Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Criteria | ME | CFS | ME/CFS | SEID | ||||
---|---|---|---|---|---|---|---|---|
Ramsay | ICC | Holmes | Australian | Oxford | Fukuda | CCC | IOM | |
Required conditions | ||||||||
Duration (months) | ≥ 6 | ≥ 6 | ≥ 6 | ≥ 6 | ≥ 6 | ≥ 6 | ||
New onset (not lifelong) | Infectious | ⊙ | ⊙ | ⊙ | ⊙ | ⊙ | ||
Fatigue (unexplained) | ● | ● | ● | ● | ⊙ | ⊙ | ||
Reduced daily activity (%) | ≥ 50 | ≥ 50 | ● | ≥ 50 | ● | ⊙ | ⊙ | |
Infective agent | ● | ● | ● | |||||
N. of symptoms required | ≥ 8 ≥ 1 (C/D), ≥ 1 (D/E), ≥ 1 (B/C) | ≥ 8(1 ≥ B) | ≥ 4 | ≥ 7 ≥ 2 (A/B), ≥ 1 (C/D/E) | ≥ 1 (B/D) | |||
No result of physical exertion | ● | ● | ||||||
No result of mental exertion | ● | ● | ||||||
No alleviation by rest | ● | ● | ● | |||||
Postexertional malaise (≥ 24 h) | ○ | ● | ⊙ | ○ | ⊙ | ● | ● | |
Inclusions | ||||||||
A. Neurologic | ||||||||
Myalgia | ○ | ⊙ | ○ | ⊙ | ⊙ | |||
Muscle weakness | ● | ⊙ | ⊙ | |||||
Motor disturbance | ○ | ⊙ | ||||||
Generalized hyperalgesia | ⊙ | |||||||
Joint pain | ⊙ | ⊙ | ⊙ | ○ | ||||
New/headaches | ○ | ⊙ | ⊙ | ⊙ | ○ | |||
Disturbed sleep patterns | ○ | ⊙ | ⊙ | ○ | ⊙ | |||
Unrefreshing sleep | ⊙ | ○ | ⊙ | ○ | ● | |||
Drowsiness | ⊙ | ○ | ○ | |||||
B. Neurocognitive | ||||||||
Difficulty thinking/processing | ⊙ | ⊙ | ○ | ⊙ | ||||
Short-term memory loss | ○ | ⊙ | ⊙ | ● | ○ | ⊙ | ⊙ | ⊙ |
Difficult to focus | ○ | ⊙ | ⊙ | ○ | ⊙ | ⊙ | ||
Depression/anxiety | ⊙ | ○ | ○ | |||||
Hypersensitivity to noise/light | ○ | ⊙ | ⊙ | ⊙ | ||||
Tinnitus, double vision | ○ | ⊙ | ||||||
C. Neuroendocrine | ||||||||
Thermostatic instability | ○ | ⊙ | ⊙ | |||||
Anorexia | ⊙ | |||||||
D. Autonomic dysfunction | ||||||||
Orthostatic intolerance | ⊙ | ⊙ | ||||||
Cardiovascular | ○ | ⊙ | ⊙ | |||||
Respiratory | ○ | ⊙ | ⊙ | |||||
Gastro-intestinal (GI) | ○ | ⊙ | ⊙ | |||||
Genito-urinary (GU) | ○ | ⊙ | ⊙ | |||||
E. Immune | ||||||||
Fever or chills | ○ | ⊙ | ||||||
Flu-like symptoms | ○ | ⊙ | ⊙ | |||||
Susceptibility to virus | ⊙ | |||||||
Sore throat | ○ | ⊙ | ⊙ | ⊙ | ||||
Lymph node pain/tenderness | ○ | ⊙ | ⊙ | ⊙ | ||||
Sensitivity to chemicals, foods, medications, odors | ⊙ | ⊙ | ||||||
Exclusions | ||||||||
Medical conditions cause chronic fatigue | x | x | x | x | x | x | ||
Psychiatric disorders | x | x | x | x | x | x | x | |
Primary brain disorders | x | x | x | x | x | |||
Substance abuse, eating disorder | x | x | x | x | x | x | ||
Active process of disease | x | x | ||||||
Reactive depression | x | |||||||
Depression and anxiety | x |