Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors

Table 2 Top ten most frequently occurred genes and mutations in our cohort that are curated by CIViC knowledge base

Gene	Number of detections	Frequency of detection %	Mutation	Number of detections	Frequency of detection %
TP53	192	61.3	KRAS p.G12D	28	8.95
APC	79	25.2	KRAS p.G13D	13	4.15
KRAS	72	23.0	TP53 p.R249S	10	3.19
EGFR	34	10.9	EGFR p.L858R	9	2.88
PIK3CA	31	9.90	KRAS p.G12V	9	2.88
SMAD4	27	8.63	KRAS p.G12C	9	2.88
ARID1A	26	8.31	TP53 p.R175H	9	2.88
CTNNB1	22	7.03	BRAF p.V600E	6	1.92
GNAQ	18	5.75	TP53 p.R273C	6	1.92
KMT2C	18	5.75	TP53 p.R273H	6	1.92

ISSN: 1479-5876