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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CLpro targeting repurposed drug candidates

Fig. 2

(a, b) Phylogenetic evolutionary relationships of SARS-CoV-2 virus showing an initial emergence in Wuhan, China, in Nov-Dec 2019 followed by continued human-to-human transmission. SARS-CoV-2 patient genome sequences deposited in GISAID database from more than 60 different countries (a) radial and (b) unrooted phylogeny created by Nextstrain program [66] (c) Pie chart representation of number of SARS-CoV-2 patient genomes deposited in GISAID till 15th April 2020 from six different regions; Asia (orange, 35.37%), Oceania (purple, 20.86%), North America (brown, 21.13%), Europe (blue, 20.31%), Africa (red, 10.35%) and South America (black, 16.63%). (d) Phylogenetic relationship of CoVs based on whole genome nucleotide sequences from bat, pangolin, and Wuhan SARS-CoV-2 (NC_045512.2) confirms that SARS-CoV-2 share > 90% similarity with bat SARS-CoV while pangolin could be the closest ancestral

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