Fig. 1

Schematic representation of SARS-CoV-2 structure showing single stranded RNA viral genomic assembly of 29,674 nucleotide base pair which encodes open reading frame 1a (ORF1a, nt 266–13,468), yellow colour, open reading frame 1b (ORF1b, nt 13,468–21,563), blue colour, Spike (S, nt 21,563–25,384), Envelope (E, nt 26,245–26,472), Membrane (M, nt 26,523–27,191) and Nucleocapsid (N, nt 28,274–29,533) proteins in green. ORF1a gene encodes papain-like protease and 3CL protease, ORF1b gene encodes RNA-dependent RNA polymerase, helicase and endo ribo-nuclease, S, E, M and N gene encodes spike, membrane glycoprotein and nucleocapsid phosphoprotein respectively. Three-dimensional crystal structure of 3CL-protese, endoribonuclease and SARS-Cov-2 spike protein receptor binding domain (RBD) engaged human angiotensin converting enzyme 2 (ACE2) receptor were collected from protein data bank