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Table 2 Management profiles during the first 3 days

From: Intensive care unit-acquired hyponatremia in critically ill medical patients

Management profiles

ICU-acquired hyponatremia (n = 217)

Normonatremia (n = 1008)

P value

Volume balancea, mL/kg

 Net

19.4 (−13.6–67.7)

11.5 (−20.8–44.9)

0.004

  Input

161.4 (117.3–245.0)

141.0 (93.6–196.7)

< 0.001

  Output

144.9 (90.4–211.7)

125.0 (86.2–178.1)

0.016

Medication

 Diuretics

150 (69.1)

675 (67.0)

0.577

  Furosemide

149 (68.7)

669 (66.4)

0.526

  Thiazide

2 (0.9)

12 (1.2)

1.000

  Spironolactone

10 (4.6)

45 (4.5)

0.858

 Sodium bicarbonate

59 (27.2)

184 (18.3)

0.004

  Mannitol

1 (0.5)

1 (0.1)

0.323

Nutrition

 Enteral nutrition

59 (27.2)

310 (30.8)

0.328

 Parenteral nutrition

30 (13.8)

168 (16.7)

0.360

Transfusion

 RBC

18 (8.3)

73 (7.2)

0.570

 Platelet

217 (23.5)

202 (20.0)

0.267

 FFP

32 (14.7)

96 (9.5)

0.027

  1. Data are presented as number (percentage) or as median (interquartile range)
  2. ICU intensive care unit, RBC red blood cell, FFP fresh frozen plasma
  3. aTotal input and output from day 0 (ICU admission) to day 2 were combined and divided by body weight