Table 1 Baseline characteristics
From: Intensive care unit-acquired hyponatremia in critically ill medical patients
Characteristic | ICU-acquired hyponatremia (n = 217) | Normonatremia (n = 1008) | P value |
|---|---|---|---|
Age, years | 64.0 (53.0–73.0) | 65.0 (55.0–74.0) | 0.347 |
Male | 141 (65.0) | 617 (61.2) | 0.317 |
SOFA | 8.0 (5.0–10.0) | 7.0 (4.0–10.0) | 0.009 |
SAPS3 | 55.0 (44.5–67.0) | 51.0 (41.0–63.0) | 0.005 |
Organ support | |||
Vasoactive agent | 76 (35.0) | 336 (33.3) | 0.635 |
Epinephrine | 9 (4.1) | 21 (2.1) | 0.088 |
Norepinephrine | 75 (34.6) | 333 (33.0) | 0.692 |
Dobutamine | 9 (4.1) | 18 (1.8) | 0.041 |
Vasopressin | 37 (17.1) | 110 (10.9) | 0.015 |
Mechanical ventilation | 127 (58.5) | 605 (60.0) | 0.703 |
Reason for admission | |||
Cardiac | 14 (6.5) | 54 (5.4) | 0.514 |
Pulmonary | 88 (40.6) | 486 (48.2) | 0.043 |
Neurologic | 4 (1.8) | 14 (1.4) | 0.542 |
Gastrointestinal | 14 (6.5) | 38 (3.8) | 0.093 |
Sepsis | 39 (18.0) | 177 (17.6) | 0.922 |
Othera | 9 (4.1) | 45 (4.5) | 1.000 |
Comorbidityb | |||
IHD | 13/160 (8.1) | 54/778 (6.9) | 0.613 |
Cardiomyopathy | 6/160 (3.8) | 19/777 (2.4) | 0.415 |
Vascular disease | 5/160 (3.1) | 23/775 (3.0) | 0.804 |
COPD | 15/160 (9.4) | 62/780 (7.9) | 0.529 |
Asthma | 3/160 (1.9) | 20/777 (2.6) | 0.783 |
ILD | 5/160 (3.1) | 41/779 (5.3) | 0.317 |
Chronic liver disease | 16/161 (9.9) | 41/778 (5.3) | 0.030 |
Hematologic malignancy | 35/162 (21.6) | 121/779 (15.5) | 0.064 |
Oncologic malignancy | 59/163 (36.2) | 300/790 (38.0) | 0.723 |
Na, mmol/L | 137.0 (135.0–138.0) | 139.0 (137.0–141.0) | < 0.001 |
K, mmol/L | 4.2 (3.7–4.7) | 4.0 (3.6–4.5) | 0.001 |
BUN, mg/dL | 22.3 (13.8–35.7) | 21.0 (14.2–30.3) | 0.140 |
Cr, mg/dL | 0.98 (0.64–1.60) | 0.88 (0.62–1.29) | 0.034 |
GFR, mL/min/1.73 m2 | 72.8 (41.4–112.4) | 81.9 (50.5–110.8) | 0.067 |