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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds

Fig. 1

Changes in brain structure occurring with aging in C57BL/6J mice. In vivo T2W MRI images are shown with single-slices from young (3 mo) or old (24 mo) mice in a and multi-slice maximum intensity projections (MaxIP) in d. The single-slice rostral view (a) is labeled with the cortex (Ct; green), hippocampus (Hi; blue), thalamus (red) and corpus callosum (Cc; purple) visible from a young and old mouse. b Quantification was carried out as linear measurements of Ct thickness superior to the Hi and Cc, across multiple locations and slices. Examples of Ct thickness measurements in the respective age groups are shown (top young mouse; bottom old mouse) with inset left hemisphere region, where the young mouse Ct thickness was about 1 mm. c The area of the two lateral ventricles was measured from the MaxIP images (*p value is less than 0.05 and #p value is less than 0.01 by ANOVA followed by Tukey multiple pairwise-comparisons). The white bar in d represents a scale bar with size of 5 mm

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