Changes in heart morphometric parameters over the course of a monocrotaline-induced pulmonary arterial hypertension rat model

Table 2 Echocardiographic and hemodynamic parameters measured at euthanasia day (mean ± SD)

Parameter	I—non-PAH control	II—early PAH	III—end-stage PAH	IV—end-stage PAH with myocarditis	p-value ANOVA or Kruskal–Wallis test	Pairwise comparisons
Parameter	I—non-PAH control	II—early PAH	III—end-stage PAH	IV—end-stage PAH with myocarditis	p-value ANOVA or Kruskal–Wallis test	p-value I vs. II	p-value I vs. III	p-value I vs. IV	p-value II vs. III	p-value II vs. IV	p-value III vs. IV
LVFWTd (mm)	0.20 ± 0.04	0.21 ± 0.03	0.19 ± 0.05	0.21 ± 0.03	0.569	ns	ns	ns	ns	ns	ns
RVFWTd (mm)	0.61 ± 0.05	0.78 ± 0.04	0.95 ± 0.20	0.88 ± 0.33	<0.001	<0.001	<0.001	0.002	0.007	0.305	1.000
TAPSE (mm)	1.11 ± 0.64	1.02 ± 0.13	0.72 ± 0.16	0.71 ± 0.14	<0.001	1.000	0.010	0.129	<0.001	<0.001	1.000
PAAT/CL (mm/s)	0.23 ± 0.15	0.21 ± 0.05	0.14 ± 0.06	0.12 ± 0.04	<0.001	1.000	0.007	0.017	0.127	0.086	1.000
LV systolic pressure (mmHg)	90.09 ± 15.90	80.50 ± 3.00	46.94 ± 14.65	43.00 ± 9.56	<0.001	1.000	<0.001	0.004	0.012	0.040	1.000
LV diastolic pressure (mmHg)	9.00 ± 4.86	7.50 ± 2.08	6.94 ± 4.02	3.50 ± 1.91	0.073	ns	ns	ns	ns	ns	ns
RV systolic pressure (mmHg)	20.20 ± 6.60	28.50 ± 5.20	45.10 ± 12.83	49.67 ± 19.91	<0.001	<0.001	<0.001	0.006	0.001	0.011	1.000
RV diastolic pressure (mmHg)	4.40 ± 2.55	8.00 ± 2.00	6.00 ± 3.89	6.67 ± 4.68	0.012	0.008	0.748	1.000	0.161	0.508	1.000

LV: left ventricle; LVFWTd: end-diastolic left ventricular free wall thickness; PAAT/CL: pulmonary artery acceleration time normalized to cycle length; PAH: pulmonary arterial hypertension; RV: right ventricle; RVFWTd: end-diastolic right ventricular free wall thickness; TAPSE: tricuspid annular plane systolic excursion
Statistically significant p-values are given in italics

ISSN: 1479-5876