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Table 1 Changes of measured morphometric parameters over the course of pulmonary arterial hypertension (mean ± SD)

From: Changes in heart morphometric parameters over the course of a monocrotaline-induced pulmonary arterial hypertension rat model

Parameter

I—non-PAH control

II—early PAH

III—end-stage PAH

IV—end-stage PAH with myocarditis

p-value ANOVA or Kruskal–Wallis test

Pairwise comparisons

p-value

I vs. II

p-value

I vs. III

p-value

I vs. IV

p-value

II vs. III

p-value

II vs. IV

p-value

III vs. IV

Body weight at 0 day (g)

313.2 ± 20.0

321.6 ± 18.2

313.7 ± 17.8

324.7 ± 11.3

0.368

ns

ns

ns

ns

ns

ns

Body weight at euthanasia day (g)

378.7 ± 58.0

367.4 ± 18.6

361.3 ± 28.3

361.4 ± 20.0

0.526

ns

ns

ns

ns

ns

ns

Body weight change

(0 day—euthanasia day) (g)

65.6 ± 56.7

45.8 ± 6.9

47.5 ± 17.6

36.7 ± 15.7

0.209

ns

ns

ns

ns

ns

ns

Heart weight (g) [indexed]

1.04 ± 0.14 [0.28 ± 0.06]

1.01 ± 0.07 [0.28 ± 0.01]

1.21 ± 0.12 [0.34 ± 0.04]

1.36 ± 0.16 [0.38 ± 0.05]

<0.001[< 0.001]

0.962

[1.000]

<0.001[0.004]

<0.001[< 0.001]

0.002[0.032]

<0.001[0.006]

0.036 [1.000]

Ventricles weight (g) [indexed]

0.87 ± 0.10 [0.23 ± 0.04]

0.85 ± 0.05 [0.23 ± 0.01]

1.01 ± 0.08 [0.28 ± 0.03]

1.15 ± 0.11 [0.32 ± 0.04]

<0.001[< 0.001]

0.894 [1.000]

<0.001[0.002]

<0.001[< 0.001]

<0.001[0.011]

<0.001[0.001]

0.005 [0.790]

RV free wall weight (g) [indexed]

0.16 ± 0.03 [0.04 ± 0.01]

0.19 ± 0.02 [0.05 ± 0.01]

0.35 ± 0.04 [0.10 ± 0.01]

0.39 ± 0.05 [0.11 ± 0.02]

<0.001[< 0.001]

0.425 [< 0.001]

<0.001[< 0.001]

<0.001[< 0.001]

<0.001[< 0.001]

<0.001[< 0.001]

0.140 [0.091]

LV free wall weight (g) [indexed]

0.37 ± 0.05 [0.10 ± 0.02]

0.35 ± 0.02 [0.09 ± 0.01]

0.28 ± 0.04 [0.08 ± 0.01]

0.32 ± 0.07 [0.09 ± 0.02]

<0.001[< 0.001]

0.736

[1.000]

<0.001[< 0.001]

0.701 [1.000]

0.053 [0.069]

1.000 [1.000]

0.103

[0.092]

LV free wall + IVS weight (g) [indexed]

0.68 ± 0.08 [0.18 ± 0.02]

0.64 ± 0.04 [0.17 ± 0.01]

0.65 ± 0.05 [0.18 ± 0.02]

0.70 ± 0.06 [0.19 ± 0.02]

0.071 [0.179]

ns

ns

ns

ns

ns

ns

IVS weight (g) [indexed]

0.29 ± 0.04 [0.08 ± 0.01]

0.31 ± 0.04 [0.08 ± 0.01]

0.35 ± 0.05 [0.10 ± 0.01]

0.41 ± 0.07 [0.11 ± 0.02]

<0.001[< 0.001]

0.751 [0.786]

<0.001[< 0.001]

<0.001[< 0.001]

0.010[< 0.001]

<0.001[< 0.001]

0.137 [0.049]

RV free wall thickness (mm) [indexed]

0.51 ± 0.14 [0.14 ± 0.04]

0.91 ± 0.14 [0.25 ± 0.04]

1.23 ± 0.25 [0.34 ± 0.09]

1.32 ± 0.20 [0.37 ± 0.07]

<0.001[< 0.001]

0.002 [0.129]

<0.001[< 0.001]

<0.001[< 0.001]

0.013[0.253]

0.002[0.188]

0.820 [1.000]

LV free wall thickness (mm) [indexed]

2.37 ± 0.42 [0.63 ± 0.13]

2.54 ± 0.42 [0.67 ± 0.10]

1.98 ± 0.41 [0.55 ± 0.13]

2.25 ± 0.50 [0.62 ± 0.13]

0.005 [0.068]

0.280 [ns]

0.004 [ns]

0.543 [ns]

0.023 [ns]

0.193 [ns]

0.380 [ns]

IVS thickness (mm) [indexed]

1.43 ± 0.33 [0.39 ± 0.14]

1.98 ± 0.36 [0.54 ± 0.09]

1.97 ± 0.37 [0.55 ± 0.13]

2.09 ± 0.49 [0.59 ± 0.17]

<0.001[0.003]

0.021[0.014]

0.020[0.010]

0.008[0.019]

1.000 [1.000]

0.950 [1.000]

0.243 [0.893]

RV diameter (mm) [indexed]

3.43 ± 0.78 [0.89 ± 0.23]

3.76 ± 0.92 [1.02 ± 0.25]

4.39 ± 0.89 [1.22 ± 0.25]

5.04 ± 0.71 [1.39 ± 0.15]

<0.001 [< 0.001]

0.865 [0.547]

0.013[< 0.001]

0.005[< 0.001]

0.456 [0.190]

0.032[0.018]

0.475

[0.320]

LV diameter (mm) [indexed]

4.77 ± 0.70 [1.27 ± 0.21]

4.81 ± 0.65 [1.31 ± 0.18]

3.03 ± 0.69 [0.83 ± 0.18]

2.96 ± 0.47 [0.82 ± 0.09]

<0.001 [< 0.001]

0.876 [0.897]

<0.001[< 0.001]

<0.001[< 0.001]

<0.001[< 0.001]

<0.001[< 0.001]

0.998 [0.993]

Pulmonary trunk diameter (mm) [indexed]

2.35 ± 0.36 [0.63 ± 0.12]

2.34 ± 0.29 [0.64 ± 0.08]

3.11 ± 0.42 [0.86 ± 0.12]

3.08 ± 0.27 [0.85 ± 0.04]

<0.001[< 0.001]

1.000 [0.992]

<0.001[< 0.001]

<0.001[< 0.001]

<0.001[< 0.001]

0.002[0.002]

0.999 [0.994]

Aorta diameter (mm) [indexed]

2.29 ± 0.21 [0.62 ± 0.10]

2.50 ± 0.33 [0.68 ± 0.09]

2.51 ± 0.25 [0.70 ± 0.10]

2.48 ± 0.40 [0.69 ± 0.12]

0.069 [0.077]

ns

ns

ns

ns

ns

ns

  1. IVS: interventricular septum; LV: left ventricle; PAH: pulmonary arterial hypertension; RV: right ventricle
  2. Statistically significant p-values are given in italics