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Table 1 Physicochemical properties of RdRP protein (YP_009725307.1)

From: Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Physiochemical properties RdRP COVID-19 Amino acid composition No. Percent composition (%)
Molecular weight 106,660.24 Ala (A) 64 6.90
No. of amino acids 932 Arg (R) 43 4.60
Theoretical pI 6.14 Asn (N) 56 6.00
Instability index 28.32 Asp (D) 75 8.00
No. of negatively charged (Asp + Glu) 106 Cys (C) 29 3.10
No. of positively charged (Arg + Lys 94 Gln (Q) 28 3.00
aliphatic index 78.43 Glu (E) 31 3.30
Grand average of hydropathicity −0.224 Gly (G) 45 4.80
Estimated half-life (mammalian reticulocytes, in vitro) 1.9 h His (H) 27 2.90
Atomic composition   Ile (I) 33 3.50
 C 4792 Leu (L) 83 8.90
 H 7265 Lys (K) 51 5.50
 N 1259 Met (M) 25 2.70
 O 1401 Phe (F) 57 6.10
 S 54 Pro (P) 30 3.20
Formula C4792H7265N1259O1401S54 Ser (S) 53 5.70
Total number of atoms 14,771 Thr (T) 61 6.50
   Trp (W) 9 1.00
   Tyr (Y) 58 6.20
   Val (V) 74 7.90
   Pyl (O) 0 0.00
   Sec (U) 0 0.00