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Table 1 Physicochemical properties of RdRP protein (YP_009725307.1)

From: Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Physiochemical properties

RdRP COVID-19

Amino acid composition

No.

Percent composition (%)

Molecular weight

106,660.24

Ala (A)

64

6.90

No. of amino acids

932

Arg (R)

43

4.60

Theoretical pI

6.14

Asn (N)

56

6.00

Instability index

28.32

Asp (D)

75

8.00

No. of negatively charged (Asp + Glu)

106

Cys (C)

29

3.10

No. of positively charged (Arg + Lys

94

Gln (Q)

28

3.00

aliphatic index

78.43

Glu (E)

31

3.30

Grand average of hydropathicity

−0.224

Gly (G)

45

4.80

Estimated half-life (mammalian reticulocytes, in vitro)

1.9 h

His (H)

27

2.90

Atomic composition

 

Ile (I)

33

3.50

 C

4792

Leu (L)

83

8.90

 H

7265

Lys (K)

51

5.50

 N

1259

Met (M)

25

2.70

 O

1401

Phe (F)

57

6.10

 S

54

Pro (P)

30

3.20

Formula

C4792H7265N1259O1401S54

Ser (S)

53

5.70

Total number of atoms

14,771

Thr (T)

61

6.50

  

Trp (W)

9

1.00

  

Tyr (Y)

58

6.20

  

Val (V)

74

7.90

  

Pyl (O)

0

0.00

  

Sec (U)

0

0.00