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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma

Fig. 1

Gene expression patterns in NSCLC. a Heatmap and clustering of all NSCLC samples (n = 530) and all genes analyzed using nCounter (NanoString). Top bar indicates the histology as assessed by pathology: green represents AD, yellow SCC and orange NSCLC NOS. Bar right of the heatmap show the correlation of each gene with the percentage of tumor cells (assessment by pathologist). Red indicates a positive correlation, blue a negative correlation. Grey boxes indicate the identified clusters that do not correlate with tumor cell percentages. b Volcano plot with the logfold change on the x-axis and FDR (−log10) on the y-axis. The 4 genes with the highest fold change are indicated. c Top 4 genes that best differentiate SCC from AD and TTF-1 expression that does not differentiate. Top bar indicates the histology as assessed by pathology: green represents AD, yellow SCC and orange NSCLC NOS. d Immune response genes show a negative correlation with the percentage of tumor cells in a sample as assessed by pathology. e Cell cycle related genes show a positive correlation with the percentage of tumor cells in a sample as assessed by pathology (cluster 2). f Immune response genes show a positive correlation with the percentage of CD8+ T cells in a sample as assessed by pathology

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