TY - JOUR AU - Brufsky, Adam AU - Marti, Juan Luis Gomez AU - Nasrazadani, Azadeh AU - Lotze, Michael T. PY - 2020 DA - 2020/06/29 TI - Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection JO - Journal of Translational Medicine SP - 261 VL - 18 IS - 1 AB - Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansion, important in the acute response in the lung; (2) as DC modulators, limiting their ability to only partially activate T cells; and (3) as prenylation inhibitors of small GTPases in the endosomal pathway of the DC to prevent expulsion of lysosomes containing SARS-CoV-2 virions. Use of ZA or other amino-bisphosphonates as modulators of COVID-19 disease should be considered. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-020-02433-6 DO - 10.1186/s12967-020-02433-6 ID - Brufsky2020 ER -