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Table 1 Multivariable Cox regression analysis of RFS in HCC patients in the discovery, validation and our patient set

From: A novel signature based on microvascular invasion predicts the recurrence of HCC

Charcateristic

Multivariable analysis

Coef

HR

Lower 95

Upper 95

z

P value

Discovery set (n = 271)

 Risk sore

1.0001

2.7186

2.1975

3.3633

9.2118

3.21E−20

 Age_ ≥ 65/, < 65

0.2566

1.2925

0.8791

1.9005

1.3048

0.1919

 Gender

− 0.0778

0.9251

0.6121

1.398

− 0.3694

0.7118

 Neoplasm-histologic-grade

− 0.1161

0.8903

0.6956

1.1394

− 0.9228

0.3561

 Pathologic_M

0.066

1.0683

0.863

1.3224

0.6071

0.5437

 Pathologic_N

0.1106

1.117

0.911

1.3695

1.0639

0.2873

 Pathologic_T

0.0183

1.0185

0.8327

1.2457

0.1785

0.8583

 Pathologic_stage

0.0231

1.0234

0.8378

1.2501

0.2268

0.8205

Validation set (n = 401)

 Riskscore

0.96

2.6117

1.5394

4.4308

3.5597

0.0004

 Age

− 0.1479

0.8625

0.6456

1.1523

− 1.0007

0.317

 Gender

− 0.1514

0.8595

0.6312

1.1703

− 0.9615

0.3363

 AJCC_T_stage

0.69193

1.9976

1.7208

2.3189

9.0928

9.66E−20

Our sets (n = 53)

 Risk.socre

1.4865

4.4217

2.0409

9.5799

3.7685

0.0002

 TNM.stag1ng

− 0.1199

0.887

0.5506

1.429

− 0.4929

0.6221

 Gender

0.6561

1.9273

0.6694

5.5486

1.2161

0.2239

 Age

0.0031

1.0031

0.407

2.4722

0.0067

0.9946