Evaluating blood–brain barrier permeability in a rat model of type 2 diabetes

Table 2 Brain areas that show no significant differences in blood–brain barrier permeability in the diabetic BBZDR/Wor rat as compared to wild type controls

Areas with nonsignificant changes in blood–brain barrier permeability
Brain area	Control			Diabetes
Brain area	Mean	SD		Mean	SD	P value
Olfactory tubercles	0.07	0.02	<	0.10	0.04	0.067
Medial pretectal area	0.00	0.16	<	0.17	0.18	0.070
Raphe magnus	0.03	0.01	<	0.05	0.02	0.088
Paraventricular nucleus	0.06	0.02	<	0.09	0.05	0.091
3rd cerebellar lobule	0.07	0.01	<	0.09	0.03	0.110
Ventral tegmental area	0.07	0.02	<	0.11	0.06	0.130
Rostral piriform ctx	0.05	0.02	<	0.07	0.03	0.143
Locus coeruleus	0.07	0.01	<	0.08	0.01	0.146
Diagonal band of Broca	0.04	0.02	<	0.06	0.03	0.157
Ventral orbital ctx	0.04	0.01	<	0.06	0.03	0.166
6th cerebellar lobule	0.04	0.01	<	0.05	0.01	0.200
Lateral orbital ctx	0.04	0.01	<	0.06	0.03	0.285
Anterior olfactory nucleus	0.05	0.01	<	0.07	0.04	0.289
Tenia tecta ctx	0.06	0.02	<	0.09	0.06	0.290
1st cerebellar lobule	0.05	0.01	<	0.06	0.02	0.353
Simple lobule cerebellum	0.09	0.01	>	0.07	0.05	0.423
Pontine nuclei	0.05	0.03	<	0.07	0.05	0.451
Pineal gland	0.86	0.04	<	0.90	0.12	0.458
Interpeduncular nucleus	0.09	0.04	<	0.11	0.08	0.522
Medial orbital ctx	0.09	0.01	>	0.08	0.05	0.526
Crus 2 of ansiform lobule	0.06	0.00		0.06	0.01	0.604
Lemniscal nucleus	0.06	0.02	<	0.07	0.03	0.611
Frontal association ctx	0.08	0.01		0.08	0.04	0.658
Crus 1 of ansiform lobule	0.06	0.01	>	0.05	0.02	0.790
4th cerebellar lobule	0.07	0.01		0.07	0.04	0.809
5th cerebellar lobule	0.07	0.01	>	0.06	0.04	0.856

ISSN: 1479-5876