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Table 1 Brain areas that have significantly greater blood–brain barrier permeability in the diabetic BBZDR/Wor rat as compared to wild type controls

From: Evaluating blood–brain barrier permeability in a rat model of type 2 diabetes

Areas with significant changes in blood–brain barrier permeability
Brain areaControl DiabetesP value
MeanSDMeanSD
Parafascicular thalamic nucleus0.030.00 < 0.080.010.000
Visual 1 ctx0.030.00 < 0.080.010.000
Entorhinal ctx0.030.01 < 0.090.010.000
Dentate gyrus ventral0.030.01 < 0.100.010.000
Medial geniculate0.030.00 < 0.110.010.000
Medial dorsal thalamic nucleus0.020.00 < 0.080.010.000
Visual 2 ctx0.030.00 < 0.090.010.000
Vuditory ctx0.030.00 < 0.080.010.000
Ventral posteriolateral thalamic nucleus0.030.00 < 0.070.010.000
Triangular septal nucleus0.020.01 < 0.070.010.000
Bed nucleus stria terminalis0.010.00 < 0.050.010.000
Inferior colliculus0.040.01 < 0.110.020.000
Posterior thalamic nucleus0.030.00 < 0.070.010.000
Dorsal lateral striatum0.020.00 < 0.060.010.000
Lateral posterior thalamic nucleus0.030.01 < 0.090.010.000
Reticular nucleus0.030.00 < 0.070.010.000
CA1 dorsal0.030.00 < 0.060.010.000
Dentate gyrus dorsal0.030.00 < 0.080.010.000
Central amygdaloid nucleus0.010.01 < 0.050.010.000
Ventral lateral striatum0.020.00 < 0.060.010.000
Reuniens nucleus0.030.00 < 0.070.010.000
Globus pallidus0.020.00 < 0.050.010.000
Lateral geniculate0.040.01 < 0.090.010.000
Dorsal medial striatum0.020.00 < 0.060.010.000
Paraventricular nucleus0.030.00 < 0.070.010.000
Retrosplenial caudal ctx0.030.01 < 0.120.020.000
Lateral septal nucleus0.020.00 < 0.060.010.000
CA20.030.00 < 0.060.010.000
Ventrolateral thalamic nucleus0.030.00 < 0.070.010.000
External plexiform layer0.070.01 < 0.120.010.000
Periaqueductal gray thalamus0.040.00 < 0.080.010.000
Temporal ctx0.030.01 < 0.120.020.000
Ventral subiculum0.040.00 < 0.080.010.000
Ventral posteriomedial thalamic nucleus0.030.00 < 0.080.010.000
Basal amygdaloid nucleus0.010.01 < 0.060.010.000
Ventromedial thalamic nucleus0.030.00 < 0.080.010.000
Parietal ctx0.030.00 < 0.060.010.000
Caudal piriform ctx0.030.00 < 0.080.020.000
Medial amygdaloid nucleus0.030.01 < 0.090.020.000
CA1 hippocampus ventral0.040.01 < 0.080.010.000
Primary somatosensory ctx barrel field0.030.00 < 0.070.010.000
Zona incerta0.040.01 < 0.080.010.000
Primary somatosensory ctx forelimb0.020.00 < 0.060.010.000
Granular cell layer0.060.01 < 0.100.010.000
Habenula nucleus0.060.01 < 0.150.030.000
Primary somatosensory ctx trunk0.030.00 < 0.060.010.000
Lateral hypothalamus0.040.00 < 0.080.020.000
Primary somatosensory ctx shoulder0.020.01 < 0.060.010.000
Ventral medial striatum0.020.00 < 0.050.010.000
Glomerular layer0.090.01 < 0.140.020.000
Prerubral field0.040.01 < 0.080.010.000
Extended amygdala0.020.00 < 0.050.010.000
Anterior hypothalamic area0.020.00 < 0.060.010.000
Primary motor ctx0.020.00 < 0.060.010.000
Secondary somatosensory ctx0.030.00 < 0.070.010.000
Intercalated amygdaloid nucleus0.010.01 < 0.070.010.000
Primary somatosensory ctx upper lip0.030.00 < 0.070.010.000
White matter rostral0.030.00 < 0.060.010.000
CA3 dorsal0.030.00 < 0.060.010.000
Posterior hypothalamic area0.040.01 < 0.100.020.000
Central medial thalamic nucleus0.040.00 < 0.070.010.000
Dorsal raphe0.040.01 < 0.080.010.000
Supramammillary nucleus0.050.01 < 0.150.040.000
Primary somatosensory ctx hindlimb0.030.00 < 0.060.010.000
Ventral anterior thalamic nucleus0.030.01 < 0.070.010.000
Lateral amygdaloid nucleus0.030.01 < 0.070.010.000
Claustrum0.020.00 < 0.050.010.000
Perirhinal ctx0.050.01 < 0.120.020.000
Lateral dorsal thalamic nucleus0.030.01 < 0.060.010.000
Dorsal medial nucleus0.030.01 < 0.070.010.000
Ectorhinal ctx0.040.01 < 0.150.050.000
Olivary nucleus0.050.01 < 0.090.020.000
Copula of the pyramis0.070.01 < 0.110.020.000
Motor trigeminal nucleus0.040.01 < 0.070.010.000
Paramedian lobule0.060.00 < 0.080.010.000
Solitary tract nucleus0.030.01 < 0.060.010.000
Parvicellular reticular areas0.040.00 < 0.060.010.000
Precuniform nucleus0.040.01 < 0.070.010.000
Anterior cingulate area0.030.00 < 0.080.020.000
Cortical amygdaloid nucleus0.050.01 < 0.100.020.000
Primary somatosensory ctx jaw0.030.01 < 0.060.010.000
Parabrachial nucleus0.050.01 < 0.080.010.000
Principal sensory nucleus trigeminal0.050.00 < 0.070.010.000
Sub coeruleus nucleus0.040.00 < 0.060.010.000
White matter caudal0.040.00 < 0.070.020.000
Endopiriform nucleus0.020.01 < 0.050.010.000
Reticular nucleus midbrain0.040.01 < 0.080.020.000
Anterior thalamic nuclei0.030.01 < 0.070.020.000
Accumbens core0.020.01 < 0.050.020.000
Prelimbic ctx0.030.00 < 0.060.020.000
7th cerebellar lobule0.030.01 < 0.060.010.000
CA3 hippocampus ventral0.040.01 < 0.080.020.000
Ventral medial nucleus0.030.01 < 0.080.030.000
Dorsal paragigantocellularis0.030.01 < 0.050.010.000
Median raphe nucleus0.040.01 < 0.060.010.000
Pedunculopontine tegmental area0.040.01 < 0.070.020.000
Secondary motor ctx0.030.01 < 0.070.020.000
Central gray0.050.00 < 0.080.010.000
Retrosplenial rostral ctx0.050.01 < 0.110.030.001
Subthalamic nucleus0.070.01 < 0.110.020.001
Medial preoptic area0.020.01 < 0.050.010.001
Medial septum0.030.01 < 0.060.010.001
Gigantocellularis reticular nucleus pons0.030.00 < 0.050.010.001
Superior colliculus0.040.01 < 0.070.020.001
Subiculum dorsal0.040.00 < 0.060.010.001
Lateral preoptic area0.020.01 < 0.050.020.001
Magnocellular preoptic nucleus0.030.01 < 0.080.030.001
Dorsomedial tegmental area0.040.01 < 0.060.020.001
Neural lobe pituitary0.140.05 < 0.260.060.001
Medial cerebellar nucleus fastigial0.060.01 < 0.080.010.001
Substantia nigra compacta0.050.01 < 0.100.030.001
8th cerebellar lobule0.040.01 < 0.060.010.001
Medial mammillary nucleus0.070.04 < 0.200.080.002
Pontine reticular nucleus caudal0.030.00 < 0.050.010.002
Flocculus cerebellum0.050.01 < 0.080.020.002
Substantia nigra reticularis0.070.02 < 0.120.030.002
Supraoptic nucleus0.050.01 < 0.080.020.002
Reticulotegmental nucleus0.030.01 < 0.050.010.003
Anterior lobe pituitary0.170.02 < 0.280.070.003
Accumbens shell0.030.01 < 0.060.020.003
Inferior olivary complex0.050.00 < 0.070.020.003
10th cerebellar lobule0.070.01 < 0.090.010.003
Infralimbic ctx0.030.01 < 0.070.020.003
Cochlear nucleus0.060.01 < 0.080.020.004
Premammillary nucleus0.050.02 < 0.110.040.004
Insular ctx0.040.01 < 0.070.020.004
Red nucleus0.050.01 < 0.080.020.004
Suprachiasmatic nucleus0.010.02 < 0.050.020.005
Root of trigeminal nerve0.050.00 < 0.070.020.005
Interposed nucleus0.060.01 < 0.080.010.006
Vestibular nucleus0.050.01 < 0.060.010.006
9th cerebellar lobule0.050.01 < 0.070.010.007
2nd cerebellar lobule0.070.01 < 0.100.020.007
Pontine reticular nucleus oral0.040.01 < 0.050.010.008
Retrochiasmatic nucleus0.050.04 < 0.130.060.009
Anterior pretectal nucleus0.030.00 < 0.070.030.009
Trapezoid body0.030.01 < 0.060.020.010
Facial nucleus0.050.01 < 0.070.020.010
Raphe obscurus nucleus0.030.01 < 0.040.010.011
Ventral pallidum0.040.01 < 0.070.020.011
Raphe linear0.060.01 < 0.080.020.012
Periolivary nucleus0.050.02 < 0.080.030.019
Dentate n. cerebellum0.050.01 < 0.060.020.019
Arcuate nucleus0.070.04 < 0.130.060.023
Substantia innominata0.050.02 < 0.090.030.024
Paraflocculus cerebellum0.060.01 < 0.070.020.026
Anterior amygdaloid nucleus0.030.01 < 0.050.030.035
  1. Areas are ranked in order of their significance (α < 0.05). False detection rate (α = 0.17)