From: Involvement of glutathione peroxidases in the occurrence and development of breast cancers
GPxs | Types | Expressions | Locations | Oxidizing substrates | Reducing substrate | Peroxidatic residue | References |
---|---|---|---|---|---|---|---|
GPx1 | Selenium-dependent | Red cells, liver, lung, and kidney | Cytosol, nucleus, and mitochondria | H2O2, soluble low MM hydroperoxides | GSH | Sec | |
GPx2 | Selenium-dependent | Gastrointestinal tract | Cytosol and nucleus | N.F. | N.F. | Sec | |
GPx3 | Selenium-dependent | Kidney, lung, epididymis, breast, heart, and muscle | Mitochondria | H2O2, soluble low MM hydroperoxides | GSH, low rate with thioredoxin and glutaredoxin | Sec | |
GPx4 | Selenium-dependent | Various tissues | Nucleus, cytosol, and mitochondria | H2O2, small hydroperoxides, hydroperoxides in complex lipids | GSH, Dithiothreitol | Sec | |
GPx5 | Non-Selenium-dependent | Epididymis | Extracellular | N.F. | N.F. | Cys | |
GPx6 | Selenium-dependent in human | Olfactory epithelium | N.A. | N.F. | N.F. | Sec (human) Cys (rats) | |
GPx7 | Non-Selenium-dependent | Preadipocytes | N.A. | H2O2 | GSH, Protein disulfide isomerase | Cys | |
GPx8 | Non-Selenium-dependent | Lung | Endoplasmic reticulum | H2O2 | GSH | Cys |