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Table 1 The types of GPxs and their proven substrates

From: Involvement of glutathione peroxidases in the occurrence and development of breast cancers

GPxsTypesExpressionsLocationsOxidizing substratesReducing substratePeroxidatic residueReferences
GPx1Selenium-dependentRed cells, liver, lung, and kidneyCytosol, nucleus, and mitochondriaH2O2, soluble low MM hydroperoxidesGSHSec[17, 83]
GPx2Selenium-dependentGastrointestinal tractCytosol and nucleusN.F.N.F.Sec[118,119,120]
GPx3Selenium-dependentKidney, lung, epididymis, breast, heart, and muscleMitochondriaH2O2, soluble low MM hydroperoxidesGSH, low rate with thioredoxin and glutaredoxinSec[17, 121]
GPx4Selenium-dependentVarious tissuesNucleus, cytosol, and mitochondriaH2O2, small hydroperoxides, hydroperoxides in complex lipidsGSH, DithiothreitolSec[122,123,124]
GPx5Non-Selenium-dependentEpididymisExtracellularN.F.N.F.Cys[17, 125]
GPx6Selenium-dependent in humanOlfactory epitheliumN.A.N.F.N.F.Sec (human)
Cys (rats)
[17, 126]
GPx7Non-Selenium-dependentPreadipocytesN.A.H2O2GSH, Protein disulfide isomeraseCys[17, 127, 128]
GPx8Non-Selenium-dependentLungEndoplasmic reticulumH2O2GSHCys[128, 129]
  1. MM molecular mass, N.F. not found, N. A. not available