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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT

Fig. 4

Evaluation of the single-gene contribution of CRIM1, NUDT15, and TPMT in predicting thiopurine toxicity after controlling for the effects of the other two genes in pediatric ALL subjects. Prediction accuracies of GVBCRIM1, GVBNUDT15, and GVBTPMT for predicting seven cutoffs of the last-cycle 6-MP DIPs (≤ 15%, ≤ 25%, ≤ 35%, ≤ 45%, ≤ 60%, ≤ 80%, and ≤ 100%) were measured using AUCs after controlling for the effects of the other two genes. 95% confidence intervals are in square brackets

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