Fig. 1

Schematic diagram of the discovery- and replication-phase data analysis steps. ALL acute lymphoblastic leukemia, WES whole-exome sequencing, SIFT sorting intolerant from tolerant, CADD combined annotation-dependent depletion, VCF variant call format, DIP dose intensity percentage, NM normal metabolizer, AMC Asan Medical Center, SNUH Seoul National University Hospital, SMC Samsung Medical Center, 6-MP 6-mercaptopurine