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Table 5 Hazard ratio for renal events by different BP patterns by criteria B

From: White-coat hypertension and incident end-stage renal disease in patients with non-dialysis chronic kidney disease: results from the C-STRIDE Study

 

Unadjusted

Model 1

Model 2

Model 3

Model 4

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

BP patterns

 NT

1.00 (ref)

1.00 (ref)

1.00 (ref)

1.00 (ref)

1.00 (ref)

 WCH

2.76 (1.55, 4.92)

1.98 (1.10, 3.58)

1.90 (1.04, 3.49)

1.90 (1.04, 3.50)

1.90 (1.04, 3.49)

 MH

4.29 (2.44, 7.53)

2.24 (1.25, 3.99)

2.23 (1.22, 4.08)

2.22 (1.21, 4.08)

2.21 (1.22, 3.99)

 SH

5.69 (3.46, 9.34)

2.04 (1.21, 3.41)

1.91 (1.08, 3.37)

1.91 (1.08, 3.37)

1.90 (1.08, 3.33)

 Clinic SBP (per 10 mm Hg)

1.28 (1.21, 1.35)

1.03 (0.94, 1.12)

1.02 (0.94, 1.12)

1.02 (0.94, 1.11)

 24 h-SBP (per 10 mm Hg)

1.32 (1.24, 1.39)

1.00 (0.91, 1.10)

 D-SBP (per 10 mm Hg)

1.31 (1.23, 1.38)

1.00 (0.92, 1.10)

 N-SBP (per 10 mm Hg)

1.30 (1.23, 1.36)

1.01 (0.93, 1.10)

 Age

1.00 (0.99, 1.01)

0.98 (0.97, 0.99)

0.98 (0.97, 0.99)

0.98 (0.97, 0.99)

0.98 (0.97, 0.99)

 Sex (M vs W)

1.32 (1.04, 1.68)

1.79 (1.29, 2.50)

1.78 (1.28, 2.48)

1.78 (1.28, 2.48)

1.78 (1.28, 2.48)

 BMI

0.95 (0.92, 0.99)

0.98 (0.95, 1.01)

0.98 (0.94, 1.01)

0.98 (0.94, 1.01)

0.98 (0.94, 1.01)

 Smoker

1.26 (0.99, 1.60)

0.88 (0.64, 1.19)

0.88 (0.64, 1.20)

0.88 (0.64, 1.20)

0.88 (0.64, 1.20)

 DM

1.79 (1.38, 2.32)

1.00 (0.61, 1.62)

1.00 (0.61, 1.63)

1.00 (0.61, 1.63)

0.99 (0.61, 1.63)

 CVD history

1.34 (0.96, 1.87)

1.27 (0.88, 1.83)

1.28 (0.89, 1.84)

1.28 (0.89, 1.84)

1.28 (0.88, 1.84)

 Anti-hypertensive treatment

0.34 (0.23, 0.51)

0.63 (0.42, 0.96)

0.64 (0.42, 0.97)

0.64 (0.42, 0.97)

0.64 (0.42, 0.97)

 Dyslipidemia

0.92 (0.69, 1.24)

0.73 (0.53, 1.00)

0.73 (0.53, 1.00)

0.73 (0.53, 1.00)

0.73 (0.53, 1.00)

  ALB

0.96 (0.95, 0.97)

0.96 (0.94, 0.98)

0.96 (0.94, 0.98)

0.96 (0.94, 0.98)

0.96 (0.94, 0.98)

 Anemia

3.70 (2.83, 4.83)

1.36 (1.00, 1.84)

1.34 (0.99, 1.82)

1.34 (0.99, 1.82)

1.34 (0.99, 1.82)

 lgUpro

4.51 (3.51, 5.81)

2.33 (1.69, 3.22)

2.31 (1.67, 3.19)

2.31 (1.67, 3.19)

2.30 (1.66, 3.19)

 eGFR

0.94 (0.93, 0.95)

0.94 (0.93, 0.95)

0.94 (0.93, 0.95)

0.94 (0.93, 0.95)

0.94 (0.93, 0.95)

Causes of CKD

 DKD vs others

2.77 (1.99, 3.88)

1.73 (0.98, 3.05)

1.73 (0.98, 3.05)

1.73 (0.98, 3.05)

1.73 (0.98, 3.05)

 GN vs others

0.95 (0.71, 1.27)

1.44 (1.06, 1.96)

1.48 (1.08, 2.03)

1.48 (1.08, 2.03)

1.48 (1.08, 2.03)

  1. NT normotension, WCH white-coat hypertension, MH masked hypertension, SH sustained hypertension, HR hazard ratio, CI confidence interval, BMI body-mass index, DM diabetes mellitus, CVD history history of CV disease, ALB serum albumin, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, GN glomerulonephritis, DKD diabetic kidney disease
  2. Model 1: adjusted for age, gender, smoker, BMI, DM, CVD history, anti-hypertensive treatment, Dyslipidemia, ALB, Anemia, logarithm transformed 24 h-urine protein, eGFR and causes of CKD
  3. Model 2: model 1 + clinic systolic blood pressures and 24-h ambulatory systolic blood pressure
  4. Model 3: model 1 + clinic systolic blood pressures and daytime systolic blood pressure
  5. Model 4: model 1 + clinic systolic blood pressures and nighttime systolic blood pressure