Table 2 Cox regression analyses of prognostic variables for OS

Sex

 Male

1.193 (1.023–1.393)

0.025

1.209 (1.035–1.413)

0.017

 Female

1

1

Age

< 0.001

< 0.001

 ≤ 60

0.550 (0.449–0.673)

< 0.001

0.492 (0.400–0.605)

< 0.001

 > 60, ≤ 70

0.699 (0.586–0.833)

< 0.001

0.747 (0.624–0.895)

0.002

 > 70

1

1

Marital status

 Unmarried

1.000 (0.856–1.168)

0.998

–

–

 Married

1

–

–

Lateral

–

–

 Left

1.019 (0.873–1.189)

0.810

–

–

 Right

1

–

–

Primary site

0.282

–

 Upper lobe

1

–

 Lower lobe

1.054 (0.885–1.256)

0.556

–

–

 Other

1.205 (0.956–1.519)

0.114

–

–

Grade

0.095

–

–

 I–II

0.625 (0.414–0.945)

0.026

–

–

 III

0.875 (0.726–1.055)

0.163

–

–

 IV

0.865 (0.713–1.049)

0.140

–

–

 Unknown

1

–

–

T stage

< 0.001

< 0.001

 T1

1

1

 T2

1.267 (1.062–1.511)

0.009

1.253 (1.046–1.501)

0.015

 T3–T4

2.106 (1.725–2.572)

< 0.001

2.000 (1.622–2.467)

< 0.001

Surgery

< 0.001

< 0.001

 Lobectomy

1

1

< 0.001

 Sublobectomy

1.659 (1.415–1.944)

< 0.001

1.444 (1.194–1.747)

< 0.001

 Pneumonectomy

2.006 (1.381–2.915)

< 0.001

1.556 (1.060–2.285)

0.024

N stage

< 0.001

0.022

 N0

1

1

 N1

1.570 (1.292–1.908)

< 0.001

1.529 (1.064–2.196)

0.022

 N2

1.865 (1.548–2.246)

< 0.001

1.572 (1.139–2.170)

0.006

LNR

< 0.001

0.005

 < 0.01

1

1

 > 0.01

1.894 (1.590–2.256)

< 0.001

1.310 (0.921–1.864)

0.1330

 NO*

2.177 (1.771–2.676)

< 0.001

1.537 (1.186–1.992)

0.001

Radiation

–

 No

1

–

–

 Yes

1.008 (0.862–1.179)

0.919

–

–

Chemotherapy

 No

1.254 (1.064–1.476)

0.007

1.525 (1.282–1.815)

< 0.001

 Yes

1

1