Fig. 2

Literature-based assessment of Medical Subject Headings (MeSH) terms, pathways, and Gene Ontology (GO) annotation associated with IBD subtype-specific gene lists. a Representation of MeSH terms associated with each IBD disease subtypes identified using our data mining approach. Briefly, genes representing IBD in general, and those uniquely related to each subtype, were identified in our Venn analysis. Each list of genes was submitted to cluster analysis using Literature Lab PLUS; clusters (outside ring labelled C-1, 2, 3, etc.) and sub-clusters (large dot on lines connected to a cluster) of MeSH terms for each disease group are shown. IBD, Inflammatory Bowel Diseases; CD Crohn’s Diseases: UC Ulcerative colitis: IBD-U IBD unclassified. b Visualization of the associated pathways in each disease subtype and with the IBD core genes. Among the pathways common to IBD and all subtypes, immune processes are highly represented. c Network focused on the key factors and major pathways involved in IBD(s) pathogenesis. The top 50 common associated genes between IBD-CD, and UC were used to generate a network map. Blue connecting lines represent pathways (i.e. the 2 genes connected share a pathway) and red lines represent physical interaction. Genes without connections are not shown in the image. Colored ellipses highlight key immune pathways: pro-inflammatory (green), IL17 (purple), and anti-inflammatory (red). d Gene set annotations with GO. GO terms significantly associated with each disease subtype were identified using GSAn and are indicated by a “X”