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Table 3 Genomic and Transcriptomic Characterization of PDOX-LM models mimicking the donor liver metastases, Related to Fig. 5

From: A novel patient-derived organoids-based xenografts model for preclinical drug response testing in patients with colorectal liver metastases

Gene symbols Log2FC P
Patient #1 PDOX-LM vs. donor liver metastases
 CDX2,TP53,POLE, AXIN2, CDK2, CDK4, AKT1 0 to 2 NA
IGF2R, APC, MDM2, KRAS, EGFR, CTNNB1, CDK6, SMAD4, BRAF, ARID1A, MTOR, SMAD2, BCL3, PI3KCA, FBXW7, MAPKAP1, ERBB2, ERBB3, AKT2, TCFL2, NRAS − 2 to 0 NA
Patient #2 PDOX-LM vs. donor liver metastases
 NRAS, KRAS ERBB3, EGFR, AXIN2, CDK4, BRAF, APC, FBXW7, TCF7L2, TP53, CDK2, MAP2K4, IGF2R 0 to 2 NA
IGF1R, MTOR, CDK6, AKT1, ARIDA1A, MDM2, AKT2, SMAD4, PI3KCA, ERBB2, CTNNB1 − 2 to 0 NA