Table 3 Genomic and Transcriptomic Characterization of PDOX-LM models mimicking the donor liver metastases, Related to Fig. 5
Gene symbols | Log2FC | P |
|---|---|---|
Patient #1 PDOX-LM vs. donor liver metastases | ||
 CDX2,TP53,POLE, AXIN2, CDK2, CDK4, AKT1 | 0 to 2 | NA |
IGF2R, APC, MDM2, KRAS, EGFR, CTNNB1, CDK6, SMAD4, BRAF, ARID1A, MTOR, SMAD2, BCL3, PI3KCA, FBXW7, MAPKAP1, ERBB2, ERBB3, AKT2, TCFL2, NRAS | − 2 to 0 | NA |
Patient #2 PDOX-LM vs. donor liver metastases | ||
 NRAS, KRAS ERBB3, EGFR, AXIN2, CDK4, BRAF, APC, FBXW7, TCF7L2, TP53, CDK2, MAP2K4, IGF2R | 0 to 2 | NA |
IGF1R, MTOR, CDK6, AKT1, ARIDA1A, MDM2, AKT2, SMAD4, PI3KCA, ERBB2, CTNNB1 | − 2 to 0 | NA |