Fig. 5

Drug response-associated mutations and gene expression. a 40 variants are associated with 30 drug action targets. The most variable variants (top 40 most variable) were summarized, different color tags represented different exonic variant subtypes. Multiple genes, including IGF2R, EGFR, POLE, AXIN2, APC, CDX2, ERBB3 and TP53, were completely identical in both donor and xenografted liver metastases. In contrast, mutations status in IGF1R, KRAS, NRAS, BRAF, TCF7L2, ERBB3, TP53, MDM2, BCL2, AKT, SMAD2, SMAD4, CTNNB1 and CDK4 were partially different. b Heatmap of gene expression associated with 30 drug action targets A total of 30 drug response-associated target gene were summarized. Both donor and xenografted liver metastases may demonstrated identical drug response to cisplatin, olaparib, PD-173074, cetuximab, trastuzumab, afatinib, AZD8931, lapatinib, trametinib, SCH772984, EMD-1214063, deltarasin, MK-2206, nutlin-3a, PD-0332991, LGK974, LY2109761, BIRB-1532 and dasatanib. In contrast, donor and xenografted liver metastases may demonstrate different response to KU55933, axitinib, sorafenib, CH5424802, taselisib, QSI-027, vorinostat, dabrafenib, BIRB 0796 and GSK126